Results 31 to 40 of about 1,799 (195)

Hashimoto’s Encephalopathy with Reversible Diffuse Leukoencephalopathy [PDF]

Journal of Neurocritical Care, 2018
Background The magnetic resonance imaging (MRI) findings of Hashimoto's encephalopathy (HE) are variable; images range from having a normal appearance, to showing ischemic lesions, demyelination, or vasogenic edema.
Woosub Hwang, Da-Eun Jeong
doaj   +1 more source

Multifocal disseminated necrotizing leukoencephalopathy as severe central nervous system toxicity from nivolumab therapy for Hodgkin lymphoma: a case report [PDF]

Encephalitis
Nivolumab, a monoclonal antibody approved in 2014 as an immune checkpoint inhibitor, offers benefits in cancer treatment but can cause serious neurological complications, including multifocal disseminated necrotizing leukoencephalopathy. We report a case
Hussein Algahtani, Bader Shirah, Mohamed Najm Aldeen Alameen, Abdulrahman Bin Saeed, Alwaleed Abdulhadi Alqahtani   +4 more
doaj   +1 more source

CSF1R ⁃ related leukoencephalopathy: from hereditary diffuse leukoencephalopathy with spheroids to primary microgliopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare autosomal dominant hereditary leukoencephalopathy. Progressive neuropsychiatric symptoms and motor disorders are the main clinical manifestations, and women appear earlier than men ...
Yan⁃qiu WEI, Jun XU, Ruo⁃xi LIU, Lin LI, Zhen DONG   +4 more
doaj  

Diagnostic features of type II fibrinoid leukodystrophy (Alexander disease) in a juvenile Beagle dog

Journal of Veterinary Internal Medicine, 2023
A 3‐month‐old female entire Beagle presented with a progressive history of caudotentorial encephalopathy. Reactive encephalopathies were ruled out and tests for the most common infectious diseases agents were negative.
Hélène Vandenberghe, Kerstin Baiker, George Nye, Leticia Escauriaza, Emma Roberts, Nicolas Granger, Lizzie Reeve   +6 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Expanding the Phenotypic Spectrum of MC3DN8: A Report of Three Patients Homozygous for the c.73G>A Variant in the LYRM7 Gene [PDF]

Annals of Child Neurology
Purpose To describe the clinical and neuroimaging features of mitochondrial complex III deficiency, nuclear type 8 (MC3DN8), associated with a recurrent leucine tyrosine arginine motif protein 7 (LYRM7) variant, and to place these findings in the context
Rafael Inácio, Patrícia Lipari Pinto, Guilherme Martins, Patrícia Janeiro, Oana Moldovan, Márcia Rodrigues, Graça Sá, Rita Jotta, Ana Gaspar, José Carlos Ferreira, Teresa Moreno, Sofia Quintas   +11 more
doaj   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Repeat expansions in leukoencephalopathy [PDF]

Annals of Neurology, 2019
Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/152577/1/ana25613.pdf ; https://deepblue.lib.umich.edu/bitstream/2027.42/152577/2/ana25613_am ...
openaire   +3 more sources

Progressive multifocal leukoencephalopathy [PDF]

Neurology, 2002
A 58-year-old woman admitted to the hospital had a 3-month history of progressive neurologic deterioration characterized by severe global aphasia and bilateral limb weakness, greater on the right. The patient had a 10-year history of systemic lupus erythematosus (SLE). Polyarthritis had been present for 6 weeks before the …
Henderson, R. D., Smith, M. G., Mowat, P., Read, S. J.   +3 more
openaire   +4 more sources