Results 31 to 40 of about 711,937 (246)

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy

Journal of Neurology, 2022
Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain—caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs.
N. Möhn, L. Grote-Levi, Franziska Hopfner, B. Eiz-Vesper, B. Maecker-Kolhoff, C. Warnke, K. Sühs, M. Wattjes, G. Höglinger, T. Skripuletz   +9 more
semanticscholar   +1 more source

A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy with mefloquine and mirtazapine

Renal Replacement Therapy, 2023
Background Progressive multifocal leukoencephalopathy is a rare disease, but the prognosis is very poor, especially in the immunosuppressed state with a non-HIV background, and there is no established treatment.
Neri Sone, Hiroki Nishiwaki, Mayu Shimokawa, Keishu Kawanishi, Tsuyoshi Oshiro, Reiji Takami, Natsuki Taira, Masahito Amagasa, Shinya Omiya, Tadahide Maezumi, Yoko Nabeshima, Kazuo Nakamichi, Yoshiharu Miura, Fumihiko Koiwa   +13 more
doaj   +1 more source

Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study

Neurotherapeutics, 2021
The main aim of the study is to evaluate the efficacy and safety profile of ocrelizumab (OCR), rituximab (RTX), and cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing–remitting multiple sclerosis (RRMS) patients at high-risk for
A. Zanghì, A. Gallo, C. Avolio, Rocco Capuano, M. Lucchini, M. Petracca, S. Bonavita, R. Lanzillo, D. Ferraro, E. Curti, M. Buccafusca, G. Callari, Stefania Barone, G. Pontillo, G. Abbadessa, Valeria Di Francescantonio, E. Signoriello, G. Lus, P. Sola, F. Granella, P. Valentino, M. Mirabella, F. Patti, E. D'Amico   +23 more
semanticscholar   +1 more source

Progressive Multifocal Leukoencephalopathy [PDF]

F1000Research, 2015
Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disease with significant morbidity and mortality and no effective, targeted therapies. It is most often observed in association with abnormalities of cell-mediated immunity, in particular human immunodeficiency virus (HIV) infection, but also occurs in association with ...
Adang, Laura, Berger, Joseph
openaire   +3 more sources

AIDS-related progressive multifocal leukoencephalopathy

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
Carolina de Oliveira Abrão, Lissa Rodrigues Machado da Silva, Luiz Carlos Silva Souza, Nathalia de Mello Bisso, Marília Dalva Turchi, Adriana Oliveira Guilarde   +5 more
doaj   +1 more source

Clinical and Radiological Characterization of Progressive Multifocal Leukoencephalopathy in HIV-Infected Patients: A Retrospective Analysis and Review of the Literature

Acta Médica Portuguesa, 2015
Introduction: Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system caused by John Cunningham virus, mostly associated with immunodeficiency conditions, such as the human immunodeficiency virus infection ...
Luís Augusto, Nélia Neves, Carina Reis, Cândida Abreu, António Sarmento   +4 more
doaj   +1 more source

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation

American Journal of Neuroradiology, 2021
BACKGROUND AND PURPOSE: There are no validated imaging criteria for the diagnosis of progressive multifocal leukoencephalopathy in the cerebellum. Here we introduce the MR imaging shrimp sign, a cerebellar white matter lesion identifiable in patients ...
N. Adra, A. Goodheart, O. Rapalino, P. Caruso, S. Mukerji, R. González, N. Venna, J. Schmahmann   +7 more
semanticscholar   +1 more source

Progressive multifocal leukoencephalopathy [PDF]

Current Neurology and Neuroscience Reports, 2000
Progressive multifocal leukoencephalopathy (PML) was a rare disease until the advent of the HIV/AIDS pandemic. Recent interest in the disorder has been spurred by its appearance in patients treated with the monoclonal antibodies natalizumab and rituximab.
openaire   +5 more sources

Risk of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patient Treated With Natalizumab: A Systematic Review

Cureus, 2021
Natalizumab, a monoclonal antibody acting on alpha4 integrin receptors, is frequently used to treat multiple sclerosis patients. The biggest downside is the risk of development of progressive multifocal leukoencephalopathy, an immune-related condition ...
G. Vivekanandan, Ansha P Abubacker, Revathi Myneni, Harshika Chawla, A. Iqbal, Amit S Grewal, Andrew Ndakotsu, Safeera Khan   +7 more
semanticscholar   +1 more source

Cerebral lesions in hematological malignancies: a case report

Journal of Medical Case Reports, 2021
Background Progressive multifocal leukoencephalopathy is a rare central nervous system disease, resulting from reactivation of latent John Cunningham virus.
Nicoletta D’Ettore, Valentina Scheggi, Brunetto Alterini, Niccolò Marchionni   +3 more
doaj   +1 more source