Results 41 to 50 of about 711,937 (246)

PARP-1 deregulation in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Poly (ADP-ribose) polymerase 1 (PARP-1) plays pivotal roles in immune and inflammatory responses. Accumulating evidence suggests PARP-1 as a promising target for immunomodulation in multiple sclerosis and natalizumab-associated progressive ...
Maria Meira, Claudia Sievers, Francine Hoffmann, Heidi Bodmer, Tobias Derfuss, Jens Kuhle, Aiden Haghikia, Ludwig Kappos, Raija LP Lindberg   +8 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy triggered by COVID-19 in a previously asymptomatic person living with undiagnosed HIV infection

International Journal of Infectious Diseases, 2023
This report presents the case of a 47-year-old male patient who worked as a mathematics teacher and experienced the sudden onset of disorientation, aphasia, and acalculia during an online class.
Yago Marcos Pessoa-Gonçalves, Thaís Soares Farnesi-de-Assunção, Marlos Aureliano Dias de Sousa, Luis Marcos Ferreira, Junior, Beatriz Sodré Matos, Anna Victória Bernardes Borges, Ana Carolina de Morais Oliveira-Scussel, Alex Eduardo da Silva, Carlo José Freire Oliveira, Marcos Vinicius da Silva, Virmondes Rodrigues, Junior   +10 more
doaj   +1 more source

Acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome: prevalence, main characteristics, and outcomes in a Brazilian center

Arquivos de Neuro-Psiquiatria, 2023
Background Progressive multifocal leukoencephalopathy (PML) - immune reconstitution inflammatory syndrome (IRIS) in people living with HIV/AIDS (PLWHA) has been rarely described in low- and middle-income countries.
Monize Nascimento Santana, Raphaela Ferrari, Arthur Cassa Macedo, Rosa Maria Nascimento Marcusso, Ruan de Andrade Fernandes, José Ernesto Vidal   +5 more
doaj   +1 more source

Immunology of progressive multifocal leukoencephalopathy [PDF]

Journal of NeuroVirology, 2015
The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV strains can turn into neurotropic JCV strains which in hereditary or acquired states of immunodeficiency cause ...
Jelcic, Ivan, Jelcic, Ilijas, Faigle, Wolfgang, Sospedra, Mireia, Martin, Roland   +4 more
openaire   +4 more sources

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
core   +1 more source

Progressive multifocal leukoencephalopathy treated with interleukin-7

Clinical Infection in Practice, 2020
Background: Progressive multifocal leukoencephalopathy (PML) is a rare devastating brain infection caused by the JC polyomavirus (JCPyV) in patients with impaired cellular immune responses. In the absence of effective anti-viral therapy, it is unclear if
Karl B. Alstadhaug, Christine Hanssen Rinaldo, Liv Osnes, Irini Sereti, Hilde K. Ofte   +4 more
doaj   +1 more source

The Pacific lineage (2E) of JC polyomavirus is prevalent in Sumba Island, Eastern Indonesia [PDF]

, 2008
Recent studies have identified a Pacific lineage (2E) of JC polyomavirus (also designated as JC virus or JCV) that occurs in both Island Southeast Asia and Oceania, but not in mainland Asia.
Nakazawa, Minato, Soemantri, Augustinus, Shimizu, Hana, Ohtsuka, Ryutaro, Shan, Zhong, Kitamura, Tadaichi, Shibuya, Ayako, Ishida, Takafumi, Yogo, Yoshiaki, Sekiyama, Makiko, Takasaka, Tomokazu, Ikegaya, Hiroshi   +11 more
core   +2 more sources

Pilot study of BKV-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy

Lancet Neurology, 2021
Background: PML, a rare disease of the central nervous system caused by JC polyomavirus (JCV) occurring in immunosuppressed people, is typically fatal unless adaptive immunity is restored.
I. Cortese, E. Beck, O. Al-Louzi, J. Ohayon, Frances Andrada, Ikesinachi Osuorah, J. Dwyer, B. Billioux, Nigar Dargah-zada, M. Schindler, Kyle Binder, L. Reoma, G. Norato, Yoshimi Enose-Akahata, Bryan R. Smith, M. C. Monaco, E. Major, S. Jacobson, D. Stroncek, S. Highfill, S. Panch, D. Reich, J. Barrett, A. Nath, P. Muranski   +24 more
semanticscholar   +1 more source

The Modern Value of Clinical Autopsies

Acta Médica Portuguesa, 2015
Keywords: Autopsy; Antiretroviral Therapy, Highly Active; HIV Infections; Leukoencephalopathy, Progressive Multifocal.
Carlos Marques Pontinha
doaj   +1 more source

Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy

JAMA Neurology
This case series investigates if directly isolated allogenic virus–specific T cells are associated with a therapeutic outcome in patients with progressive multifocal leukoencephalopathy (PML).
N. Möhn, L. Grote-Levi, M. P. Wattjes, A. Bonifacius, Dennis Holzwart, Franziska Hopfner, S. Nay, Sabine Tischer-Zimmermann, M. L. Sassmann, P. Schwenkenbecher, K. Sühs, N. Mahmoudi, C. Warnke, Julian Zimmermann, D. Hagin, L. Goudeva, Rainer Blasczyk, Armin Koch, B. Maecker-Kolhoff, B. Eiz-Vesper, G. Höglinger, T. Skripuletz   +21 more
semanticscholar   +1 more source