Results 41 to 50 of about 12,469 (206)

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

The Pacific lineage (2E) of JC polyomavirus is prevalent in Sumba Island, Eastern Indonesia [PDF]

, 2007
Recent studies have identified a Pacific lineage (2E) of JC polyomavirus (also designated as JC virus or JCV) that occurs in both Island Southeast Asia and Oceania, but not in mainland Asia.
Ryutaro Ohtsuka, Yoshiaki Yogo, Makiko Sekiyama, Shimizu, Hana, Ayako Shibuya, Hiroshi Ikegaya, Minato Nakazawa, Kitamura, Tadaichi, Shibuya, Ayako, Yogo, Yoshiaki, Ikegaya, Hiroshi, Hana Shimizu, Augustinus Soemantri, Takafumi Ishida, Nakazawa, Minato, Soemantri, Augustinus, Zhong Shan, Ohtsuka, Ryutaro, Tadaichi Kitamura, Shan, Zhong, Ishida, Takafumi, Tomokazu Takasaka, Sekiyama, Makiko, Takasaka, Tomokazu   +23 more
core   +1 more source

A Case of Progressive Multifocal Leucoencephalopathy and Cerebral Toxoplasmosis in an HIV-Infected Patient

Acta Medica Bulgarica, 2023
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system (CNS) caused by the reactivation of John Cunningham polyomavirus (JCV).
Yancheva-Petrova N., Grozdeva R., Nikolova M., Aleksiev I., Rainova I., Tsvetkova N., Strashimirov D.   +6 more
doaj   +1 more source

Natalizumab-associated progressive multifocal leukoencephalopathy

Frontiers in Neurology
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain resulting from infection of oligodendrocytes by JC virus (JCV) typically occurring in association with defects of cell-mediated immunity.
Trevor Glenn, Joseph R. Berger, Caleb R. S. McEntire   +2 more
doaj   +1 more source

JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient

BMC Neurology, 2022
Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML).
Xiang Wang, Jinxiu Chen, Jing Gong, Ying Wu, Xiang-hao Liu   +4 more
doaj   +1 more source

Real‐World Safety and Effectiveness of Glatiramer Acetate in Patients With Multiple Sclerosis: Final Results of Post‐Marketing Surveillance in Japan

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino, Eriko Hayashi, Mai Itani, Jun‐ichi Kira   +3 more
wiley   +1 more source

Eculizumab-related progressive multifocal leukoencephalopathy

, 2015
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the CNS caused by reactivation of the polyomavirus JC (JCV). In the context of immunosuppression, JCV can reactivate and spread to brain infecting oligodendrocytes ...
Ivanovic Barbeito, Yerko, Ramos González, Ana, Gómez Cibera, Emilio, Villarejo Galende, Alberto, Hilario Barrio, Amaya, Gutiérrez Martínez, Eduardo, Abradelo De Usera, Manuel, Ruíz Morales, Juan, Morales Ruiz, Enrique   +8 more
core   +1 more source

Progressive multifocal leukoencephalopathy in an HIV patient: A case report and literature review

Clinical Case Reports, 2023
Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the brain caused by reactivation of the JC virus, which can lead to a lytic infection of oligodendrocytes.
Ting Lei, Ai Deng, Lianchi Li, Ming Wang, Dongbo Wu, Taoyou Zhou   +5 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy therapy [PDF]

Journal of NeuroVirology, 2014
Progressive multifocal leukoencephalopathy (PML) is caused by the JC virus in the setting of chronic immune deficiency. Developing therapy has been challenged by the rarity of the disease as well as the complexity of patients in whom it develops. Several small trials directed at presumptive antiviral therapies have failed to show convincing clinical ...
openaire   +2 more sources