Results 41 to 50 of about 21,234 (200)

Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy

Case Reports in Infectious Diseases, 2016
Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes.
Chandra Punch, Christina Schofield, Penelope Harris   +2 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy in an AIDS Patient

Journal of the Formosan Medical Association, 2007
Progressive multifocal leukoencephalopathy (PML) is a demyelinating brain disease caused by Jamestown Canyon virus (JCV). This disease is an important cause of morbidity and mortality in acquired immunodeficiency syndrome (AIDS) patients.
Ming-Hsing Lee, Yan-Zhong Chen, Yung-Hsiang Hsu   +2 more
doaj   +1 more source

Does Mefloquine (Lariam®) Therapy Improve the Prognosis of Human JC Polyomavirus-Induced Progressive Multifocal Leukoencephalopathy? [PDF]

Journal of Biomedical & Clinical Research, 2014
Progressive multifocal leukoencephalopathy (PML) is ademyelinating disease caused by infection with Polyomavirus hominis 2, popularly known as JC virus (JCV).
Zlatko Kalvatchev, Iliya Tsekov
doaj   +3 more sources

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source

Mild progressive multifocal leukoencephalopathy after switching from natalizumab to ocrelizumab

Neurology: Neuroimmunology & Neuroinflammation, 2020
Objective To describe the disease course of carryover progressive multifocal leukoencephalopathy (PML) after switching from natalizumab to ocrelizumab in 2 patients with relapsing-remitting MS.
Alyssa A. Toorop, Z. V. van Lierop, E. Strijbis, C. Teunissen, A. Petzold, M. Wattjes, F. Barkhof, B. D. de Jong, Z. V. van Kempen, J. Killestein   +9 more
semanticscholar   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Natalizumab-associated progressive multifocal leukoencephalopathy

Frontiers in Neurology
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain resulting from infection of oligodendrocytes by JC virus (JCV) typically occurring in association with defects of cell-mediated immunity.
Trevor Glenn, Joseph R. Berger, Caleb R. S. McEntire   +2 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy in an HIV patient: A case report and literature review

Clinical Case Reports, 2023
Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the brain caused by reactivation of the JC virus, which can lead to a lytic infection of oligodendrocytes.
Ting Lei, Ai Deng, Lianchi Li, Ming Wang, Dongbo Wu, Taoyou Zhou   +5 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy therapy [PDF]

Journal of NeuroVirology, 2014
Progressive multifocal leukoencephalopathy (PML) is caused by the JC virus in the setting of chronic immune deficiency. Developing therapy has been challenged by the rarity of the disease as well as the complexity of patients in whom it develops. Several small trials directed at presumptive antiviral therapies have failed to show convincing clinical ...
openaire   +2 more sources

Allogeneic BK Virus–Specific T Cells for Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 2018
&NA; JC virus, the cause of progressive multifocal leukoencephalopathy (PML), and the BK virus are genetically similar and share sequence homology in immunogenic proteins.
M. Muftuoglu, A. Olson, D. Marin, Saira S. Ahmed, V. Mulanovich, S. Tummala, L. Chi, A. Ferrajoli, I. Kaur, Li Li, R. Champlin, E. Shpall, K. Rezvani   +12 more
semanticscholar   +1 more source