Results 41 to 50 of about 43,456 (236)

Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy [PDF]

, 2016
Cognitive impairment is an inevitable feature of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting executive function, attention and processing speed from an early stage.
Cullen, Breda, Kalladka, Dheeraj, Krishnadas, Rajeev, López-González, Maria R., Moreton, Fiona C., Muir, Keith W., Santosh, Celestine, Schwarzbauer, Christian, Stringer, Michael S.   +8 more
core   +1 more source

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy [PDF]

, 2006
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Barkhof, F., Clifford, D.B., Curfman, B., Fahle, G., Fischer, S., Habil, M., Hou, J., Jäger, H.R., Major, E.O., Miszkiel, K., Mueller-Lenke, N., Radue, E.-W., Ryschkewitsch, C., Sanchez, E., Yousry, T.A.   +14 more
core   +1 more source

The Primary Microglial Leukodystrophies: A Review [PDF]

, 2022
Primary microglial leukodystrophy or leukoencephalopathy are disorders in which a genetic defect linked to microglia causes cerebral white matter damage.
Ferrer, Isidro (Ferrer Abizanda)
core   +1 more source

Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus

Brazilian Journal of Infectious Diseases
Progressive multifocal leukoencephalopathy is a neurological infectious disease caused by the John Cunningham polyomavirus (JCV), an opportunistic agent with worldwide distribution.
Fabrício Guimarães Gonçalves, Leslie Lamb, Raquel Del Carpio-O'Donovan   +2 more
doaj   +1 more source

Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation

Анналы клинической и экспериментальной неврологии, 2020
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) on magnetic resonance spectroscopy is a rare and little-known form of hereditary leukoencephalopathy, a significant portion of which is probably obscured by the ...
Alexander Yu. Kazantsev, Tatiana V. Matveeva   +1 more
doaj   +1 more source

Rare anoxic brain injury sequela of delayed posthypoxic leukoencephalopathy due to recreational drug overdose with benzodiazepines

Clinical Case Reports, 2020
A growth in recreational drug use will lead to a rise in delayed posthypoxic leukoencephalopathy cases. Physicians may inadvertently misdiagnose this rare condition as a primary psychiatric disorder by not maintaining a broad differential diagnosis.
Kara Kaplan, Ariful Alam, Braydon Dymm, Hisham Valiuddin, Sangeetha Nanthabalan   +4 more
doaj   +1 more source

Mitochondrial myopathy and comorbid major depressive disorder. effectiveness of dTMS on gait and mood symptoms [PDF]

, 2015
Background: Mitochondrial myopathies (MMs) often present with leukoencephalopathy and psychiatric symptoms, which do not respond to or worsen with psychiatric drugs.
Angeletti, Gloria, Brugnoli, Roberto, Callovini, G, Dacquino, Claudia, Danese, E, DEL CASALE, Antonio, Ferracuti, Stefano, Ferri, Vr, Gentile, Giovanna, Girardi, Paolo, Janiri, D, Kotzalidis, Georgios, Manfredi, G, Raccah, Rn, Rapinesi, Chiara, Scatena, P, Serata, D, Simmaco, Maurizio, Zangen, A   +18 more
core   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes [PDF]

, 2019
Objective: To expand the clinical spectrum of lysyl-tRNA synthetase (KARS) gene–related diseases, which so far includes Charcot-Marie-Tooth disease, congenital visual impairment and microcephaly, and nonsyndromic hearing impairment.
Antonellis, Anthony, Donaldson, Kevin, Emrick, Lisa, Gao, Mingshi, Hou, Ya-Ming, Jiang, Yanjun, Lalani, Seema R., Landsverk, Megan L., Lee, Sansan, Lewis, Andrea M., Li, Meixia, Li, Yuxin, Lin, Jie, Lu, Jiahong, Luo, Sushan, Magoulas, Pilar L., Mei, Hui, Niu, Zhiyv, Oprescu, Stephanie N., Person, Richard E., Rosenfeld, Jill A., Slavin, Thomas P., Song, Jie, Sun, Chong, Walkiewicz, Magdalena, Wang, Yin, Xi, Jianying, Yang, Yaping, Zhang, Victor W., Zhao, Chongbo   +29 more
core   +1 more source

Detection of Vascular Leukoencephalopathy in CT Images [PDF]

Artificial Intelligence XLI. SGAI 2024. Lecture Notes in Computer Science, vol 15446. Springer, Cham (2025)
Artificial intelligence (AI) has seen a significant surge in popularity, particularly in its application to medicine. This study explores AI's role in diagnosing leukoencephalopathy, a small vessel disease of the brain, and a leading cause of vascular dementia and hemorrhagic strokes.
arxiv   +1 more source