Results 81 to 90 of about 4,419 (217)

Precision oncology to overcome resistance in R/R AML in children and adults requires combinations of cytotoxic, targeted, and immunological treatments

Journal of Internal Medicine, Volume 298, Issue 4, Page 297-318, October 2025.
Abstract Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including ...
Martin Jädersten, Ingrid Lilienthal, Christer Nilsson, Louisa Fredrikson, Cornelis Jan Pronk, Kristian Løvvik Juul‐Dam, Mika Kontro, Nikolas Herold   +7 more
wiley   +1 more source

Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature [PDF]

, 2015
Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% [1]. Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases [2 ...
Daniel Johnson, Gautam Borthakur, Koji Sasaki, Merry Chen, Michael Kwon, Naval Daver, Naveen Pemmaraju, Rivka R. Colen, Sairah Ahmed, Vahid Afshar-Kharghan, Yang Huh   +10 more
core   +3 more sources

IGH::IL3‐Rearranged B‐Cell Precursor Acute Lymphoblastic Leukemia With Hypereosinophilia in a Child With a Novel PAX5 Germline Variant

Genes, Chromosomes and Cancer, Volume 64, Issue 9, September 2025.
ABSTRACT B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) with the t(5;14)(q31;q32) chromosomal translocation resulting in an IGH::IL3 fusion is an exceptionally rare lymphoid malignancy presenting with hypereosinophilia. Germline PAX5 alterations, including sequence variants and deletions, are associated with a selective susceptibility to BCP ...
Bartosz Urbański, Karolina Miarka‐Walczyk, Zuzanna Urbańska, Marta Wąsikowska, Elżbieta Sałacińska‐Łoś, Karolina Bukowska‐Strakova, Monika Lejman, Ewelina Jaroszek, Barbara Piątosa, Wojciech Młynarski, Agata Pastorczak, Szymon Janczar   +11 more
wiley   +1 more source

Chronic myeloid leukaemia presenting as priapism: A report of 2 cases and review of literature

International Journal of Medicine and Health Development, 2010
Introduction: Chronic myeloid leukaemia (CML) patients with hyperleukocytosis may demonstrate signs or symptoms of leukostasis including priapism. Methods: We report two patients with CML who presented with priapism.
S Ocheni, O G Ibegbulam, D B Olusina, A A Oyekunle, M A Durosinmi   +4 more
doaj   +1 more source

Bone Marrow-Derived Stem Cells:A Mixed Blessing in the Multifaceted World of Diabetic Complications [PDF]

, 2016
Diabetes is one of the main economic burdens in health care, which threatens to worsen dramatically if prevalence forecasts are correct. What makes diabetes harmful is the multi-organ distribution of its microvascular and macrovascular complications ...
Madeddu, Paolo, Mangialardi, Giuseppe
core   +3 more sources

Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

MedComm, Volume 6, Issue 9, September 2025.
This study illustrates how high glucose triggers glycolysis, ROS production, and lactic acid accumulation, leading to TXNIP upregulation and PANOptosome formation. These complexes activate apoptosis (cleaved caspase‐3), pyroptosis (GSDME), and necroptosis (MLKL), contributing to diabetic retinopathy.
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li   +8 more
wiley   +1 more source

Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis. [PDF]

, 1999
peer reviewedTranslocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly.
Albert Thiry, Berger, Bitter, Christian Herens, Fleischman, Fonatsch, Francoise Tassin, Georges Fillet, Griggs, Horsman, Jean-Philippe Hermanne, Kwong, Kwong, Levaltier, Lucien Koulischer, Marie France Fassotte, Mauricette Jamar, Mecucci, Nicole Schaaf-Lafontaine, Prigogina, Secker-Walker, Whang-Peng, Yunis   +22 more
core   +1 more source

Inflammatory and angiogenic protein detection in the human vitreous : cytometric bead assay [PDF]

, 2011
Introduction. To evaluate clinical feasibility and reproducibility of cytometric bead assay (CBA) in nondiluted vitreous samples of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and central retinal vein occlusion ...
Koch, Frank H., Koss, Michael Janusz, Pfister, Marcel   +2 more
core  

FLT-3 ITD Positive Acute Basophilic Leukemia with Rare Complex Karyotype Presenting with Acute Respiratory Failure: Case Report

Romanian Journal of Laboratory Medicine, 2018
Background: Acute basophilic leukemia is a rare subtype of acute myeloid leukemia, as categorized by the 2008 World Health Organization classification of myeloid neoplasms. Acute basophilic leukemia diagnosis requires thorough morphological, cytochemical,
Antohe Ion, Dăscălescu Angela, Dănăilă Cătălin, Zlei Mihaela, Ivanov Iuliu, Sireteanu Adriana, Boca Oana, Oană Raluca, Cianga Petru   +8 more
doaj   +1 more source

Maternal immune system adaptation to pregnancy - a potential influence on the course of diabetic retinopathy [PDF]

, 2010
Background Progression of diabetic retinopathy occurs at least temporarily during pregnancy. Although the cause of this progression is not entirely understood, the immune phenomenon and chronic inflammation may play a significant role.
Snježana Kaštelan, Martina Tomić, Josip Pavan, Slavko Orešković   +3 more
core   +2 more sources