Results 91 to 100 of about 3,520 (213)

In silico Identification of Novel Toxin Homologs and Associated Mobile Genetic Elements in Clostridium perfringens

Pathogens, 2019
Clostridium perfringens causes a wide range of diseases in a variety of hosts, due to the production of a diverse set of toxins and extracellular enzymes. The C.
Jake A. Lacey, Priscilla A. Johanesen, Dena Lyras, Robert J. Moore   +3 more
doaj   +1 more source

Antibacterial and Osteogenic Applications of Ti‐Cu Alloys: A Review of Current Research and Future Directions

Advanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.
Given the growing interest in antibiotic‐free implant strategies and the need for biocompatible solutions to combat peri‐implantitis and implant failure, this review gives a timely and comprehensive overview of Ti‐Cu alloys as next‐generation biomaterials.
Brandon Fields, Elliot Makhani, Benjamin Makhani, Justin Cortez, Vivek Verma, Alexander Dupuy, Hamoun Sabri, Hom‐Lay Wang, Alexander Groetsch   +8 more
wiley   +1 more source

Membrane Association and Destabilization by Aggregatibacter Actinomycetemcomitans Leukotoxin Requires Changes in Secondary Structures

, 2013
Aggregatibacter actinomycetemcomitans is a common inhabitant of the upper aerodigestive tract of humans and non-human primates and is associated with disseminated infections, including lung and brain abscesses, pediatric infective endocarditis in ...
Lally, E. T., Boesze-Battaglia, K., Walters, M. J., Boesze-Battaglia, Kathleen, Walters, Michael J., Lally, Jennifer T., Edrington, T. C., Brown, Angela C., Baranwal, Somesh, Du, Y., Brown, A. C., Edrington, Thomas C., Baranwal, S., Du, Yurong   +13 more
core   +1 more source

Pasteurellaceae leukotoxin A sequences considered as reference sequences for reference-based assemblies and phylogenetics.

, 2023
Pasteurellaceae leukotoxin A sequences considered as reference sequences for reference-based assemblies and phylogenetics.
Kevin A. Blecha (17241414), Christopher A. W. MacGlover (17241411), Mark D. Stenglein (7459655), Karen A. Fox (6085475)   +3 more
core   +1 more source

Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

Pathogens, 2019
Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation ...
Georgios N. Belibasakis, Terhi Maula, Kai Bao, Mark Lindholm, Nagihan Bostanci, Jan Oscarsson, Riikka Ihalin, Anders Johansson   +7 more
doaj   +1 more source

Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and ...
Gilliana Rozenblum, Karima Ait‐Aissa, Gadeer Zahran, Mahdieh Alipour, Amal M. Sahyoun, Undral Munkhsaikhan, Adam Kassan, Tauheed Ishrat, Qi Wang, Ammaar H. Abidi, Modar Kassan   +10 more
wiley   +1 more source

Activation of bovine neutrophils by Pasteurella haemolytica leukotoxin is calcium dependent

, 1992
In this study, we used the fluorescent probe Fluo-3 to show that an increase in cytosolic free calcium, [Ca2+]i, occurred when suspensions of bovine neutrophils were incubated with sublethal concentrations of P. haemolytica leukotoxin.
O Ortiz-Carranza, CJ Czuprynski
core   +1 more source

The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target

Immunity, Inflammation and Disease, Volume 13, Issue 11, November 2025.
This review focuses on the pivotal role and specific mechanisms of periodontal tissue destruction by excess ROS, which mediate signaling pathways such as nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK), as well as the activation of OS response‐associated proteins, including thioredoxin‐interacting protein (TXNIP) and ...
Shuyu Yang, Xi Yang
wiley   +1 more source

Gut Microbiota and Bacterial Extracellular Vesicles: Emerging Roles in Myocardial Remodelling and Cardiac Health

Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.
The gut microbiota is capable of secreting bacterial extracellular vesicles (BEVs), which can carry cytoplasmic components, including enzymes and nucleic acids. BEVs have the ability to penetrate the intestinal epithelial barrier, enter the circulatory system and ultimately reach the heart.
Mingyang Chang, Tiantian Xia, Nan Zhang, Qianqian Zhao, Pan Shen, Ningning Wang, Chaoji Huangfu, Zhijie Bai, Dezhi Sun, Yangyi Hu, Shuman Li, Zhexin Ni, Wei Zhou, Yue Gao   +13 more
wiley   +1 more source

Characterization and serotype distribution of Aggregatibacter actinomycetemcomitans detected in a population of periodontitis patients in Spain.

, 2009
Objective: To investigate the serotype distribution of Aggregatibacter actinomycetemcomitans (A. a.) and the polymorphism of the genes that codify the leukotoxin (ltx) and the operon of the cytolethal distending toxin (cdt) in periodontitis patients in ...
Blasi, Andrea
core