Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis [PDF]
Aggregatibacter actinomycetemcomitans is an oral pathogen and etiologic agent of localized aggressive periodontitis. The bacterium is also a cardiovascular pathogen causing infective endocarditis. A.
Scott C. Kachlany +5 more
doaj +3 more sources
Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97 [PDF]
peer-reviewedStaphylococcus aureus is an important pathogen associated with both human and veterinary disease and is a common cause of bovine mastitis. Genomic heterogeneity exists between S.
Budd, Kathleen E +5 more
core +11 more sources
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis +5 more
wiley +1 more source
The role of the host—Neutrophil biology
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Leukotoxins are the critical virulence factors of several Gram-positive and Gram-negative bacteria [...]
openaire +3 more sources
Staphylococcus aureus Leukotoxin GH Promotes Inflammation [PDF]
Staphylococcus aureus produces numerous molecules that facilitate survival in the host. We recently identified a novel S. aureus leukotoxin (leukotoxin GH [LukGH]) using proteomics, but its role in virulence remains unclear. Here we investigated the role of LukGH in vivo.We tested cytotoxicity of LukGH toward polymorphonuclear leukocytes (PMNs) from ...
Natalia, Malachowa +6 more
openaire +2 more sources
Severe Necrotizing Community-Acquired Pneumonia and Bilateral Empyema in an Immunocompetent Patient due to <i>Fusobacterium necrophorum</i>. [PDF]
Necrotizing pneumonia and empyema caused by Fusobacterium necrophorum are uncommon. The classical presentation of Lemierre′s syndrome, characterized by pharyngotonsillitis and internal jugular vein thrombosis, is not always observed, and incomplete and atypical variants can cause diagnostic uncertainty and delay in treatment.
Shefa D +6 more
europepmc +2 more sources
Immunosuppressive properties of Actinobacillus actinomycetemcomitans leukotoxin [PDF]
Actinobacillus actinomycetemcomitans produces a leukotoxin that kills human polymorphonuclear cells (PMNs) and monocytes but not lymphocytes. In this study, we examined A. actinomycetemcomitans leukotoxin for its ability to alter human peripheral blood lymphocyte (HPBL) responsiveness.
G, Rabie, E T, Lally, B J, Shenker
openaire +2 more sources
Characterization of Fusobacterium isolates from the respiratory tract of white-tailed deer (Odocoileus virginianus) [PDF]
A total of 23 clinical isolates of Fusobacterium spp. were recovered at necropsy over a 2-year period from the respiratory tract of white-tailed deer (Odocoileus virginianus).
Brooks, Jason W. +6 more
core +1 more source
Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes. [PDF]
ABSTRACT Periodontal disease is a prevalent and chronic inflammatory condition increasingly recognized for its systemic implications beyond oral health. While traditionally confined to dentistry, recent evidence reveals strong associations between periodontitis and chronic systemic conditions such as cardiovascular disease, diabetes mellitus ...
El Chaar E.
europepmc +2 more sources

