Results 31 to 40 of about 3,055 (179)

Leukotoxin and pyrogenic toxin Superantigen gene backgrounds in bloodstream and wound Staphylococcus aureus isolates from eastern region of China

BMC Infectious Diseases, 2018
Background The bicomponent leukotoxins and the pyrogenic toxin superantigens (PTSAgs) are important virulence factors of Staphylococcus aureus. It is necessary to survey the prevalence and expression of these toxin-encoding genes for understanding the ...
Chunyan He, Su Xu, Huanqiang Zhao, Fupin Hu, Xiaogang Xu, Shu Jin, Han Yang, Fang Gong, Qingzhong Liu   +8 more
doaj   +1 more source

Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature

Pathogens, 2019
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease.
Niels Nørskov-Lauritsen, Rolf Claesson, Anne Birkeholm Jensen, Carola Höglund Åberg, Dorte Haubek   +4 more
doaj   +1 more source

Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis

Journal of Oral Microbiology, 2014
For decades, Aggregatibacter actinomycetemcomitans has been associated with aggressive forms of periodontitis in adolescents. In the middle of the 1990s, a specific JP2 clone of A.
Dorte Haubek, Anders Johansson
doaj   +1 more source

The Highly Leukotoxic JP2 Genotype of Aggregatibacter actinomycetemcomitans Is Present in the Population of the West African Island, Sal in Cape Verde: A Pilot Study

Pathogens, 2022
Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a ...
Johannes J. De Soet, Rolf Claesson, Dorte Haubek, Anders Johansson, Mark J. Buijs, Catherine M. C. Volgenant   +5 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis

Frontiers in Immunology, 2019
Aggregatibacter actinomycetemcomitans (Aa) is a low-abundance Gram-negative oral pathobiont that is highly associated with a silent but aggressive orphan disease that results in periodontitis and tooth loss in adolescents of African heritage.
Daniel H. Fine, Amey G. Patil, Senthil K. Velusamy   +2 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles

Toxins, 2018
The Gram-negative bacterium, Aggregatibacter actinomycetemcomitans, has been associated with localized aggressive periodontitis (LAP). In particular, highly leukotoxic strains of A.
Justin B. Nice, Nataliya V. Balashova, Scott C. Kachlany, Evan Koufos, Eric Krueger, Edward T. Lally, Angela C. Brown   +6 more
doaj   +1 more source

Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin

Pathogens, 2019
Leukotoxic potential of Aggregatibacter actinomycetemcomitans strains has been studied by the use of several methods, and results differ depending on the methods used.
Anne Birkeholm Jensen, Marianne Lund, Niels Nørskov-Lauritsen, Anders Johansson, Rolf Claesson, Jesper Reinholdt, Dorte Haubek   +6 more
doaj   +1 more source

Prevalence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and Oral Hygiene Practice of Kenyan Adolescents in Maasai Mara

Pathogens, 2021
Aggregatibacter actinomycetemcomitans is implicated in the etiology of periodontitis that affects adolescents. The monitoring and mapping of the geographic dissemination pattern of JP2 and non-JP2 genotypes of A. actinomycetemcomitans are of interest. In
Dorte Haubek, Tonnie Mulli, Arthur Kemoli, Mark Lindholm, Hans Gjørup, Marie-Louise Milvang Nørregaard, Anders Johansson   +6 more
doaj   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source