Leukotoxin of Bibersteinia trehalosi Contains a Unique Neutralizing Epitope, and a Non-Neutralizing Epitope Shared with Mannheimia haemolytica Leukotoxin [PDF]
Toxins, 2018 Bibersteinia trehalosi and Mannheimia haemolytica, originally classified as Pasteurella haemolytica biotype T and biotype A, respectively, under Genus Pasteurella has now been placed under two different Genera, Bibersteinia and Mannheimia, based on DNA ...
Arumugam Murugananthan +2 more
exaly +6 more sources
Evolution of the leukotoxin promoter in genus
BMC Evolutionary Biology, 2009 Background The Mannheimia species encompass a wide variety of bacterial lifestyles, including opportunistic pathogens and commensals of the ruminant respiratory tract, commensals of the ovine rumen, and pathogens of the ruminant integument.
Bisgaard Magne +7 more
doaj +7 more sources
Toxins, 2011 Aggregatibacter actinomycetemcomitans has been described as a member of the indigenous oral microbiota of humans, and is involved in the pathology of periodontitis and various non-oral infections. This bacterium selectively kills human leukocytes through
Anders Johansson, Johansson Anders
exaly +6 more sources
Therapeutic Applications of Aggregatibacter actinomycetemcomitans Leukotoxin [PDF]
PathogensAggregatibacter actinomycetemcomitans is a Gram-negative oral bacterium that has been primarily studied for its role in causing periodontal disease. The bacterium has also been implicated in several systemic diseases such as endocarditis and soft tissue ...
Scott C. Kachlany, Brian A. Vega
doaj +4 more sources
Diversity and evolution of leukotoxin operons in Staphylococcus aureus [PDF]
mSystemsStaphylococcus aureus is a globally significant and opportunistic pathogen equipped with a diverse arsenal of virulence factors, including bi-component leukotoxins that play a central role in immune evasion and tissue damage. Despite extensive functional
Stephanie S. R. Souza +2 more
doaj +2 more sources
A fast and simple assay to quantify bacterial leukotoxin activity [PDF]
Electronic Journal of Biotechnology, 2016 Background: Mannheimia haemolytica is the primary bacterial pathogen in causing bovine respiratory disease with tremendous annual losses in the cattle industry. The leukotoxin from M. haemolytica is the predominant virulence factor.
Tobias Oppermann +3 more
doaj +3 more sources
Scientific Reports, 2017 Aggregatibacter actinomycetemcomitans leukotoxin (LtxA) is a major virulence factor that kills leukocytes permitting it’s escape from host immune surveillance. A. actinomycetemcomitans strains can produce high or low levels of toxin.
Vandana Sampathkumar +3 more
doaj +2 more sources
The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis
Journal of Oral Microbiology, 2017 Aggregatibacter actinomycetemcomitans is a Gram-negative periodontitis-associated bacterium that expresses a toxin that selectively affects leukocytes. Leukotoxin is encoded by an operon belonging to the core genome of this bacterial species.
Anders Johansson +4 more
doaj +2 more sources
Chrysin and Luteolin from Moroccan Propolis to Prevent Aggressive Periodontitis Caused by Aggregatibacter actinomycetemcomitans Leukotoxin: A Computer-Aided Drug Design Approach [PDF]
PharmaceuticalsBackground: Aggregatibacter actinomycetemcomitans is a Gram-negative, facultative anaerobic, immobile oral bacterium responsible for the secretion of virulence factors, namely leukotoxin (LtxA), a large exotoxin of the RTX family that enables the ...
Doha EL Meskini +6 more
doaj +2 more sources
Prevalence of systemic immunoreactivity to
BMC Infectious Diseases, 2011 Background Chronic infections and associated inflammatory markers are suggested risk factors for cardiovascular disease (CVD). The proinflammatory cytokine, interleukin (IL)-1β, is suggested to play a role in the regulation of local inflammatory ...
Jansson Jan-Håkan +6 more
doaj +2 more sources