Results 41 to 50 of about 3,520 (213)

Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans

BMC Research Notes, 2012
Background Aggregatibacter actinomycetemcomitans produces a leukotoxin that activates a pro-inflammatory death of human monocytes/macrophages. A specific clone of this bacterium (JP2) has a 530-base pair deletion in the leukotoxin promoter gene and ...
Kwamin Francis, Gref Rolf, Haubek Dorte, Johansson Anders   +3 more
doaj   +1 more source

Molecular and phylogenetic study of Staphylococcus aureus isolated from human and cattle of Al-Qadisiyah Governorate, Iraq [PDF]

Veterinary World, 2019
Aim: This study was designed to detect the prevalence of Staphylococcus aureus, to estimate the frequency of methicillin resistance gene (mecA), femA (specific gene for S.
Ahmed Jasim Neamah, Hayder Naji Ayyez, Saba Falah Klaif, Yahia Ismail Khudhair, Muthanna Hadi Hussain   +4 more
doaj   +1 more source

Leukotoxin and pyrogenic toxin Superantigen gene backgrounds in bloodstream and wound Staphylococcus aureus isolates from eastern region of China

BMC Infectious Diseases, 2018
Background The bicomponent leukotoxins and the pyrogenic toxin superantigens (PTSAgs) are important virulence factors of Staphylococcus aureus. It is necessary to survey the prevalence and expression of these toxin-encoding genes for understanding the ...
Chunyan He, Su Xu, Huanqiang Zhao, Fupin Hu, Xiaogang Xu, Shu Jin, Han Yang, Fang Gong, Qingzhong Liu   +8 more
doaj   +1 more source

Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature

Pathogens, 2019
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease.
Niels Nørskov-Lauritsen, Rolf Claesson, Anne Birkeholm Jensen, Carola Höglund Åberg, Dorte Haubek   +4 more
doaj   +1 more source

Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes. [PDF]

J Diabetes
ABSTRACT Periodontal disease is a prevalent and chronic inflammatory condition increasingly recognized for its systemic implications beyond oral health. While traditionally confined to dentistry, recent evidence reveals strong associations between periodontitis and chronic systemic conditions such as cardiovascular disease, diabetes mellitus ...
El Chaar E.
europepmc   +2 more sources

Receptor-Based Peptides for Inhibition of Leukotoxin Activity [PDF]

ACS Infectious Diseases, 2018
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans, commonly associated with localized aggressive periodontitis (LAP), secretes an RTX (repeats-in-toxin) protein leukotoxin (LtxA) that targets human white blood cells, an interaction that is driven by its recognition of the lymphocyte function-associated antigen-1 (LFA-1) integrin.
Eric Krueger, Shannon Hayes, En Hyung Chang, Shailagne Yutuc, Angela C. Brown   +4 more
openaire   +2 more sources

Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis

Journal of Oral Microbiology, 2014
For decades, Aggregatibacter actinomycetemcomitans has been associated with aggressive forms of periodontitis in adolescents. In the middle of the 1990s, a specific JP2 clone of A.
Dorte Haubek, Anders Johansson
doaj   +1 more source

The Highly Leukotoxic JP2 Genotype of Aggregatibacter actinomycetemcomitans Is Present in the Population of the West African Island, Sal in Cape Verde: A Pilot Study

Pathogens, 2022
Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a ...
Johannes J. De Soet, Rolf Claesson, Dorte Haubek, Anders Johansson, Mark J. Buijs, Catherine M. C. Volgenant   +5 more
doaj   +1 more source

Staphylococcus aureus Leukotoxin GH Promotes Inflammation [PDF]

The Journal of Infectious Diseases, 2012
Staphylococcus aureus produces numerous molecules that facilitate survival in the host. We recently identified a novel S. aureus leukotoxin (leukotoxin GH [LukGH]) using proteomics, but its role in virulence remains unclear. Here we investigated the role of LukGH in vivo.We tested cytotoxicity of LukGH toward polymorphonuclear leukocytes (PMNs) from ...
Natalia, Malachowa, Scott D, Kobayashi, Kevin R, Braughton, Adeline R, Whitney, Michael J, Parnell, Donald J, Gardner, Frank R, Deleo   +6 more
openaire   +2 more sources

Leukotoxin

, 2005
Actinobacillus actinomycetemcomitans produces a leukotoxin that selectively kills human leukocytes. Recently, we reported that macrophages are highly sensitive to leukotoxin and that their lysis involves activation of caspase 1.
A. Johansson, Lerner, Ulf,, P. Kelk, Hänström, L, Kalfas, S, U. H. Lerner, Claesson, R, R. Claesson, Lerner, Ulf H,, Claesson, Rolf,, L. Hänström, Johansson, Anders,, Kelk, P, S. Kalfas, Hänström, L,, Kelk, Peyman,, Johansson, A   +16 more
core   +1 more source