Results 41 to 50 of about 2,921 (175)

Identification and characterization of the Pasteurella haemolytica leukotoxin [PDF]

Infection and Immunity, 1987
The identification and chromatographic characterization of the leukotoxin of Pasteurella haemolytica is described. The toxin, which has an apparent native molecular weight of greater than 400,000 as judged by gel exclusion chromatography, has a 105-kilodalton (105K) polypeptide as its major protein component.
Y F, Chang, R, Young, D, Post, D K, Struck   +3 more
openaire   +2 more sources

Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis

Journal of Oral Microbiology, 2014
For decades, Aggregatibacter actinomycetemcomitans has been associated with aggressive forms of periodontitis in adolescents. In the middle of the 1990s, a specific JP2 clone of A.
Dorte Haubek, Anders Johansson
doaj   +1 more source

The Highly Leukotoxic JP2 Genotype of Aggregatibacter actinomycetemcomitans Is Present in the Population of the West African Island, Sal in Cape Verde: A Pilot Study

Pathogens, 2022
Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a ...
Johannes J. De Soet, Rolf Claesson, Dorte Haubek, Anders Johansson, Mark J. Buijs, Catherine M. C. Volgenant   +5 more
doaj   +1 more source

Secretion of the Pasteurella leukotoxin by Escherichia coli [PDF]

FEMS Microbiology Letters, 1989
Nucleic acid sequence analysis has indicated that the leukotoxin determinant from Pasteurella haemolytica is related to the hemolysin determinant from E. coli. The cloning and expression in E. coli of the lktCA genes has been previously reported, but the existence of leukotoxin secretory genes equivalent to hlyBD has not been documented. In this report
Y F, Chang, R, Young, T L, Moulds, D K, Struck   +3 more
openaire   +2 more sources

Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis

Frontiers in Immunology, 2019
Aggregatibacter actinomycetemcomitans (Aa) is a low-abundance Gram-negative oral pathobiont that is highly associated with a silent but aggressive orphan disease that results in periodontitis and tooth loss in adolescents of African heritage.
Daniel H. Fine, Amey G. Patil, Senthil K. Velusamy   +2 more
doaj   +1 more source

Screen for Leukotoxin Mutants in Aggregatibacter actinomycetemcomitans : Genes of the Phosphotransferase System Are Required for Leukotoxin Biosynthesis [PDF]

Infection and Immunity, 2008
ABSTRACT Aggregatibacter (formerly Actinobacillus ) actinomycetemcomitans is a pathogen that causes localized aggressive periodontitis and extraoral infections including infective endocarditis. Recently, we reported that A.
Maria P, Isaza, Matthew S, Duncan, Jeffrey B, Kaplan, Scott C, Kachlany   +3 more
openaire   +2 more sources

Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles

Toxins, 2018
The Gram-negative bacterium, Aggregatibacter actinomycetemcomitans, has been associated with localized aggressive periodontitis (LAP). In particular, highly leukotoxic strains of A.
Justin B. Nice, Nataliya V. Balashova, Scott C. Kachlany, Evan Koufos, Eric Krueger, Edward T. Lally, Angela C. Brown   +6 more
doaj   +1 more source

Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin

Pathogens, 2019
Leukotoxic potential of Aggregatibacter actinomycetemcomitans strains has been studied by the use of several methods, and results differ depending on the methods used.
Anne Birkeholm Jensen, Marianne Lund, Niels Nørskov-Lauritsen, Anders Johansson, Rolf Claesson, Jesper Reinholdt, Dorte Haubek   +6 more
doaj   +1 more source

Prevalence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and Oral Hygiene Practice of Kenyan Adolescents in Maasai Mara

Pathogens, 2021
Aggregatibacter actinomycetemcomitans is implicated in the etiology of periodontitis that affects adolescents. The monitoring and mapping of the geographic dissemination pattern of JP2 and non-JP2 genotypes of A. actinomycetemcomitans are of interest. In
Dorte Haubek, Tonnie Mulli, Arthur Kemoli, Mark Lindholm, Hans Gjørup, Marie-Louise Milvang Nørregaard, Anders Johansson   +6 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source