Results 51 to 60 of about 3,520 (213)

Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis

Frontiers in Immunology, 2019
Aggregatibacter actinomycetemcomitans (Aa) is a low-abundance Gram-negative oral pathobiont that is highly associated with a silent but aggressive orphan disease that results in periodontitis and tooth loss in adolescents of African heritage.
Daniel H. Fine, Amey G. Patil, Senthil K. Velusamy   +2 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles

Toxins, 2018
The Gram-negative bacterium, Aggregatibacter actinomycetemcomitans, has been associated with localized aggressive periodontitis (LAP). In particular, highly leukotoxic strains of A.
Justin B. Nice, Nataliya V. Balashova, Scott C. Kachlany, Evan Koufos, Eric Krueger, Edward T. Lally, Angela C. Brown   +6 more
doaj   +1 more source

Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin

Pathogens, 2019
Leukotoxic potential of Aggregatibacter actinomycetemcomitans strains has been studied by the use of several methods, and results differ depending on the methods used.
Anne Birkeholm Jensen, Marianne Lund, Niels Nørskov-Lauritsen, Anders Johansson, Rolf Claesson, Jesper Reinholdt, Dorte Haubek   +6 more
doaj   +1 more source

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase [PDF]

Nature Medicine, 1997
Leukotoxin is a linoleic acic oxide produced by leukocytes and has been associated with the multiple organ failure and adult respiratory distress syndrome seen in some severe burn patients. Leukotoxin has been reported to be toxic when injected into animals intravenously.
Moghaddam, Mehran F., Grant, David F., Cheek, Jeffrey M., Greene, Jessica F., Williamson, Kristin C., Hammock, Bruce D.   +5 more
openaire   +2 more sources

Humoral immune response to Aggregatibacter actinomycetemcomitans leukotoxin

, 2010
Background and Objective: Periodontal disease is an inflammatory condition caused by bacterial infections that result in loss of the tooth supporting tissue.
A. Holmlund, A. Johansson, Johansson, Anders,, Holmlund, Anders,, Holmlund, A,, Brage, M., M. Brage, Johansson, A., Brage, Monica,   +8 more
core   +1 more source

Prevalence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and Oral Hygiene Practice of Kenyan Adolescents in Maasai Mara

Pathogens, 2021
Aggregatibacter actinomycetemcomitans is implicated in the etiology of periodontitis that affects adolescents. The monitoring and mapping of the geographic dissemination pattern of JP2 and non-JP2 genotypes of A. actinomycetemcomitans are of interest. In
Dorte Haubek, Tonnie Mulli, Arthur Kemoli, Mark Lindholm, Hans Gjørup, Marie-Louise Milvang Nørregaard, Anders Johansson   +6 more
doaj   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED [PDF]

Nature, 2012
Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi-component leukotoxins that are toxic towards neutrophils, but also specifically target other immune cells.
III, Francis Alonzo, Kozhaya, Lina, Rawlings, Stephen A., Reyes-Robles, Tamara, DuMont, Ashley L., Myszka, David G., Landau, Nathaniel, Unutmaz, Derya, Torres, Victor J.   +8 more
openaire   +2 more sources

Leukotoxin production by Fusobacterium necrophorum biotypes

, 1990
Fusobacterium necrophorum biotypes A and B were grown anaerobically to detect their leukotoxin production. Both biotypes exerted the highest leukotoxic effect on bovine leukocytes in the late logarithmic and early stationary growth places.
Chengappa, M. M., Nagaraja, Tiruvoor G., Tiruvoor G. Nagaraja, Z. Tan, M. M. Chengappa, Tan, Z.   +5 more
core   +1 more source