The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target. [PDF]
This review focuses on the pivotal role and specific mechanisms of periodontal tissue destruction by excess ROS, which mediate signaling pathways such as nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK), as well as the activation of OS response‐associated proteins, including thioredoxin‐interacting protein (TXNIP) and ...
Yang S, Yang X.
europepmc +2 more sources
Molecular and phylogenetic study of Staphylococcus aureus isolated from human and cattle of Al-Qadisiyah Governorate, Iraq [PDF]
Aim: This study was designed to detect the prevalence of Staphylococcus aureus, to estimate the frequency of methicillin resistance gene (mecA), femA (specific gene for S.
Ahmed Jasim Neamah +4 more
doaj +1 more source
A guide to chemokines and their receptors [PDF]
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
core +1 more source
Background Chronic infections and associated inflammatory markers are suggested risk factors for cardiovascular disease (CVD). The proinflammatory cytokine, interleukin (IL)-1β, is suggested to play a role in the regulation of local inflammatory ...
Jansson Jan-Håkan +6 more
doaj +1 more source
A three-way comparative genomic analysis of Mannheimia haemolytica isolates [PDF]
Background Mannhemia haemolytica is a Gram-negative bacterium and the principal etiological agent associated with bovine respiratory disease complex. They transform from a benign commensal to a deadly pathogen, during stress such as viral infection and ...
Paulraj K Lawrence +3 more
core +2 more sources
Monoclonal antibodies to leukotoxin of Actinobacillus actinomycetemcomitans [PDF]
Hybridoma cell lines which produce monoclonal antibodies to a leukotoxin from Actinobacillus actinomycetemcomitans were prepared. The monoclonal antibodies were selected for their ability to neutralize the cytotoxic activity of the leukotoxin and recognize the toxin on nitrocellulose blots. The antibodies belonged to either the immunoglobulin G1 (IgG1)
J M, DiRienzo +4 more
openaire +2 more sources
Comparative protection of small ruminants against Mannheimia haemolytica infection by inactivated bacterin and toxoid vaccines [PDF]
Background and Aim: Mannheimia haemolytica causes respiratory infection and mortality in sheep and goats, similar to the effects in cattle, which causes major economic damage.
Dounia Bkiri +4 more
doaj +1 more source
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor. [PDF]
AIMS: Endothelial-derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and selective sEH inhibitor that was tested in two phase I studies.
Abraham +40 more
core +2 more sources
Aggregatibacter actinomycetemcomitans has been described as a member of the indigenous oral microbiota of humans, and is involved in the pathology of periodontitis and various non-oral infections. This bacterium selectively kills human leukocytes through
Anders Johansson
doaj +3 more sources
A fast and simple assay to quantify bacterial leukotoxin activity
Background: Mannheimia haemolytica is the primary bacterial pathogen in causing bovine respiratory disease with tremendous annual losses in the cattle industry. The leukotoxin from M. haemolytica is the predominant virulence factor.
Tobias Oppermann +3 more
doaj +1 more source

