Results 221 to 230 of about 98,896 (358)

Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study. [PDF]

Pediatr Nephrol
Saad N, Osman A, Mansour M, Bakr AM.
europepmc   +1 more source

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This graphical abstract illustrates that SCD1 inhibition by A939572 or the targeted nanovesicle POCM‐NP@A939572 reprograms arachidonic acid metabolism via the COX1‐HPGDS‐PGD2 axis and impairs mitochondrial homeostasis, thereby suppressing osteoclastogenesis and alleviating bone loss in osteoporosis.
Yihao Zhao, Xiaoan Wei, Haihao Wu, Chengjun Yao, Zeyu Zheng, Weishao Chen, Zhenhua Feng, Bao Huang, Zimin Cai, Qize Xue, Jian Chen, Fengdong Zhao, Junhui Liu   +12 more
wiley   +1 more source

Successful treatment of chronic spontaneous urticaria and bladder pain syndrome with montelukast and/or omalizumab: a case report. [PDF]

J Med Case Rep
Bulut G.
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre-Clinical Rodent Model. [PDF]

Prenat Diagn
Forde B, Finoti S, Oria M, Peiro JL.
europepmc   +1 more source

Chemical Profiling, Pharmacological Activities, and Toxicity Assessment of Juniperus phoenicea sp. turbinata L. Extract: Integrated In Vitro, In Vivo, and In Silico Insights

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Hydroethanolic leaf and fruit extracts of Juniperus phoenicea showed high phenolic content, dominated by ferulic acid. Both extracts were non‐toxic and exhibited strong anti‐inflammatory, analgesic, antioxidant, and antimicrobial activities. Molecular docking confirmed stable binding to key inflammatory and microbial targets, supporting its ...
Tarik Chelouati, Soufyane Lafraxo, Amira Metouekel, Mostafa Messkini, Salah‐eddine Chebaibi, Abdelfattah E. L. Moussaoui, Azeddin El Barnossi, Esmael M. Alyami, Ohoud A. Alghamdi, Yousef A. Bin Jardan, Gehan M. Elossaily, Musaab Dauelbait, Musa A. Said, Ahmed Samir Benjelloun   +13 more
wiley   +1 more source

DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis. [PDF]

Nat Commun
Luo W, Xu W, Yin Q, Song J, Wang J, Guan Y, Huang J, Yu J, Zou K, Jin D, Xu C, Qiu M, Qiu Z, Zhong J.   +13 more
europepmc   +1 more source

The pediatric asthma yardstick: Practical recommendations for a sustained step-up in asthma therapy for children with inadequately controlled asthma [PDF]

, 2018
Bacharier, Leonard B, Chipps, Bradley E, Farrar, Judith R, Jackson, Daniel J, Murphy, Kevin R, Phipatanakul, Wanda, Szefler, Stanley J, Teague, W. Gerald, Zeiger, Robert S   +8 more
core   +2 more sources

Comparative Study of Inhaled Corticosteroids and Leukotriene Receptor Antagonists As Controller Options for Mildly to Moderately Persistent, Stable Asthma [PDF]

Jamal Shah, Fahad Siddiqui, Samran Hasan Adnan, M. F. Saleem, Nadia Siddiqui, Yousuf Qamar, Sami Ullah, Mehwish Khan, Arif Ullah   +8 more
openalex   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source