Results 231 to 240 of about 98,896 (358)

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

open access: yesMedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang   +28 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

open access: yesMedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang   +7 more
wiley   +1 more source

Platelet-macrophage cooperation drives IL-33-dependent type 2 lung immunopathology in a sex-biased manner. [PDF]

open access: yesJ Allergy Clin Immunol
Hayashi H   +14 more
europepmc   +1 more source

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

open access: yesObesity, Volume 34, Issue 5, Page 1056-1067, May 2026.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran   +11 more
wiley   +1 more source

Efficacy of tiotropium in adults with moderate asthma, by leukotriene receptor antagonist use at baseline

open access: gold, 2018
Shu Hashimoto   +5 more
openalex   +1 more source

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