Results 301 to 310 of about 98,896 (358)
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Clinical Science, 1984
Background: Feldberg & Kellaway [1] were the first to demonstrate the formation and release from envenomed dog and monkey lungs of a substance which caused a delayed and slow contraction of the guinea-pig jejunum; subsequently, Kellaway & Trethewie [2] described release of a slow-reacting substance (SRS) during acute anaphylaxis of the guinea ...
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Background: Feldberg & Kellaway [1] were the first to demonstrate the formation and release from envenomed dog and monkey lungs of a substance which caused a delayed and slow contraction of the guinea-pig jejunum; subsequently, Kellaway & Trethewie [2] described release of a slow-reacting substance (SRS) during acute anaphylaxis of the guinea ...
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Prostaglandins and leukotrienes
Current Opinion in Immunology, 1989The eicosanoids are a group of substances with wideranging biological activities which are produced in cells from polyunsaturated fatty acids, particularly arachidonic acid (AA). The enzymes initially involved in the production of eicosanoids and their primary products are a cyclooxygenase, which forms prostaglandin (PG) eridoperoxides, and the various
C W, Parker, W F, Stenson
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Molecular and Cellular Biochemistry, 1985
The in vitro metabolism of leukotriene B4 is initiated by omega-hydroxylation. This reaction is followed by oxidation of the omega-hydroxyl group to a carboxyl group. In vivo extensive beta-oxidation occurs and the main excreted products after administration of leukotriene B4 are water and carbon dioxide. Experiments performed in vitro and in vivo have
S, Hammarström +2 more
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The in vitro metabolism of leukotriene B4 is initiated by omega-hydroxylation. This reaction is followed by oxidation of the omega-hydroxyl group to a carboxyl group. In vivo extensive beta-oxidation occurs and the main excreted products after administration of leukotriene B4 are water and carbon dioxide. Experiments performed in vitro and in vivo have
S, Hammarström +2 more
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Prostaglandins, 1980
A previously introduced nomenclature for leukotrienes is extended on the basis of the nature of the cysteine substituent and the total number of double bonds in new and earlier described compounds.
B, Samuelsson, S, Hammarström
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A previously introduced nomenclature for leukotrienes is extended on the basis of the nature of the cysteine substituent and the total number of double bonds in new and earlier described compounds.
B, Samuelsson, S, Hammarström
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The Discovery of the Leukotrienes
American Journal of Respiratory and Critical Care Medicine, 2000In a study of the transformation of polyunsaturated fatty acids in rabbit polymorphonuclear leukocytes in 1976 it was discovered that arachidonic acid is oxygenated at C-5 (1). Subsequently a number of derivatives, including leukotriene B 4 (LTB 4 ), were identified (2-4).
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Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
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Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
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American Journal of Respiratory and Critical Care Medicine, 2000
Allergic rhinitis is characterized by the symptoms of nasal itch, sneezing, rhinorrhea, and nasal stuffiness with, in addition, in more severe and chronic disease the development of mucosal swelling that results in impaired sinus drainage, loss of sense of smell, and alteration in eustachian tube function (1).
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Allergic rhinitis is characterized by the symptoms of nasal itch, sneezing, rhinorrhea, and nasal stuffiness with, in addition, in more severe and chronic disease the development of mucosal swelling that results in impaired sinus drainage, loss of sense of smell, and alteration in eustachian tube function (1).
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American Journal of Respiratory and Critical Care Medicine, 1998
Abstract Leukotrienes are potent pro-inflammatory mediators that appear to contribute to pathophysiologic features of asthma. For example, cysteinyl leukotrienes contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting eosinophils ...
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Abstract Leukotrienes are potent pro-inflammatory mediators that appear to contribute to pathophysiologic features of asthma. For example, cysteinyl leukotrienes contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting eosinophils ...
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Lipoxygenases and leukotrienes
Journal of Allergy and Clinical Immunology, 1984Abstract Some characteristics of lipoxygenases in general and 5-lipoxygenases in particular are discussed.
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Journal of Receptor Research, 1989
Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions.
J P, Cristol, B, Provençal, P, Sirois
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Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions.
J P, Cristol, B, Provençal, P, Sirois
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