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Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B
Biochemical and Biophysical Research Communications, 1980Abstract Leukotriene A was assigned the structure 5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid by the enzymatic conversion of a synthetic product of known stereochemistry into the naturally occurring isomer of 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes.
O, Rådmark +6 more
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Leukotriene A4: Enzymatic conversion to leukotriene C4
Biochemical and Biophysical Research Communications, 1980Abstract An unstable epoxide, leukotriene A4 (5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid), was earlier proposed to be an intermediate in the conversion of arachidonic acid into the slow reacting substance (SRS), leukotriene C4.
O, Rådmark, C, Malmsten, B, Samuelsson
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A novel leukotriene formed by transpeptidation of leukotriene E
Biochemical and Biophysical Research Communications, 1982Abstract A new leukotriene 5(S)-hydroxy-6(R)- S -γ-glutamylcysteine-7,9- trans -11,14- cis -eicosatetraenoic acid (leukotriene F4) was isolated after incubating leukotriene E4 with γ-glutamyltranspeptidase and glutathione. Leukotriene F4 induced contractions of the isolated quinea pig ileum and was less potent in this respect than ...
K, Bernström, S, Hammarström
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Prostaglandins, 1986
Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with increasing protein concentration, saturable binding and rapid dissociation of binding by excess unlabelled leukotriene B4. Dissociation
S, Charleson +7 more
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Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with increasing protein concentration, saturable binding and rapid dissociation of binding by excess unlabelled leukotriene B4. Dissociation
S, Charleson +7 more
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Cardiovascular effects of leukotrienes
Cardiovascular Drugs and Therapy, 1989Leukotrienes are among the most potent lipid mediators of inflammation. Leukotriene B4 is one of the most potent endogenously synthesized chemotactic substances. It is probable that LTB4 plays an important role in the initial phase of the inflammatory reaction.
J, Fauler, J C, Frölich
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Agents and Actions, 1986
In conclusion the leukotrienes appear to fulfill the major criteria as mediators of inflammation. They have been shown to be present at a variety of inflammatory sites and to be generated by cells involved in inflammatory sequelae following an inflammatory stimulus.
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In conclusion the leukotrienes appear to fulfill the major criteria as mediators of inflammation. They have been shown to be present at a variety of inflammatory sites and to be generated by cells involved in inflammatory sequelae following an inflammatory stimulus.
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Pharmacology of the Leukotrienes
1985Leukotrienes are a new family of metabolites of arachidonic acid produced by a C-5 lipoxygenase. As shown on figure 1, leukotriene A4, the key compound in their biosynthesis could either be hydrolysed to form leukotriene B4 or combine with glutathione to form leukotriene C4.
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Journal of Lipid Mediators and Cell Signalling, 1995
The current challenge in research on leukotriene receptors is to clone these molecules. Traditional protein purification approaches have not been successful in providing sequence information. Solubilization of cys-LT1 has been achieved but results in the dissociation of G-proteins and the loss of high affinity binding (Mong et al., 1986b; Mong and ...
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The current challenge in research on leukotriene receptors is to clone these molecules. Traditional protein purification approaches have not been successful in providing sequence information. Solubilization of cys-LT1 has been achieved but results in the dissociation of G-proteins and the loss of high affinity binding (Mong et al., 1986b; Mong and ...
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