Leukotriene antagonists in dermatology
Indian Journal of Dermatology, 2021 Leukotriene antagonists constitute an important group of drugs in the therapeutic armamentarium of all dermatologists. It has been quite valuable in the management of various types of urticaria and atopic dermatitis. Recently, the role of zileuton in the
Aditya Kumar Bubna
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Aspirin-Exacerbated Asthma [PDF]
Allergy, Asthma & Clinical Immunology, 2008 This review focuses on aspirin-exacerbated asthma (AEA). The review includes historical perspective of aspirin, prevalence, pathogenesis, clinical features and treatment of AEA.
Varghese Mathew, Lockey Richard F
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Leukotriene Receptor Antagonists and Related Compounds [PDF]
Canadian Respiratory Journal, 1999 Leukotrienes (LTs), lipid mediators of inflammation, have proved to be important biochemicals involved in the symptoms and physiological changes of asthma.
Sally E Wenzel
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Structure-based identification of compounds with potential as selective BLT1 antagonists [PDF]
Scientific ReportsThe pro-inflammatory molecule leukotriene B4 binds to the leukotriene B4 receptors 1 and 2 (BLT1 and BLT2). Although BLT1 has potential as a target for treating inflammatory diseases, no selective BLT1 antagonist has been marketed to date.
Reem A. Alkhodier +3 more
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Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho database: The Shizuoka study [PDF]
Epilepsia OpenObjective Managing the risk of epileptic seizures in older adults is increasingly important as the population ages. Leukotriene receptor antagonists (LTRAs) are commonly used to treat asthma or allergic rhinitis.
Yutaro Imaichi +5 more
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Leukotriene Receptor Antagonists for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-analysis [PDF]
Acta Dermato-VenereologicaAtopic dermatitis is a chronic skin condition with no cure. Current conventional treatments can have many side effects or are expensive. Emerging evidence suggests leukotriene receptor antagonists could serve as a corticosteroid-sparing option. This meta-
Safa Fawaza Mahmood +5 more
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The Employment of Leukotriene Antagonists in Cutaneous Diseases Belonging to Allergological Field [PDF]
Mediators of Inflammation, 2010 Leukotrienes (LTs) are potent biological proinflammatory mediators. LTC4, LTD4, and LTE4 are more frequently involved in chronic inflammatory responses and exert their actions binding to a cysteinyl-LT 1 (CysLT1) receptor and a cysteinyl-LT 2 (CysLT2 ...
Eustachio Nettis +6 more
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Leukotriene Receptor Antagonists [PDF]
Seminars in Respiratory and Critical Care Medicine, 2002 In the past decade, heightened emphasis has been placed on the importance of inflammation in the pathogenesis of asthma. Although corticosteroids have remained the primary anti-inflammatory agents in the management of the persistent asthmatic, new classes of drugs have recently been added.
Marzena E, Krawiec, Nizar J, Jarjour
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An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. [PDF]
PLoS ONE, 2013 While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory ...
David M Tobin +4 more
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Leukotrienes, leukotriene receptor antagonists, and rhinitis [PDF]
Allergy, 2000 A series of clinical studies have shown the ef®cacy of leukotriene (LT) receptor antagonists (LTRAs) in the treatment of bronchial asthma (1±6). LTRAs relieve bronchospasm, prevent exercise-induced asthma, and reduce bronchial hyperresponsiveness.
N, Mygind, R, Dahl, H, Bisgaard
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