Results 11 to 20 of about 11,937 (148)

Leukotriene Antagonists in Dermatology. [PDF]

Indian J Dermatol, 2021
Leukotriene antagonists constitute an important group of drugs in the therapeutic armamentarium of all dermatologists. It has been quite valuable in the management of various types of urticaria and atopic dermatitis. Recently, the role of zileuton in the management of acne has been elaborated, and in the near future it could ...
Bubna AK.
europepmc   +5 more sources

Leukotriene Receptor Antagonists [PDF]

Seminars in Respiratory and Critical Care Medicine, 2002
In the past decade, heightened emphasis has been placed on the importance of inflammation in the pathogenesis of asthma. Although corticosteroids have remained the primary anti-inflammatory agents in the management of the persistent asthmatic, new classes of drugs have recently been added.
Marzena E, Krawiec, Nizar J, Jarjour
exaly   +3 more sources

Structure-based identification of compounds with potential as selective BLT1 antagonists. [PDF]

Sci Rep
The pro-inflammatory molecule leukotriene B4 binds to the leukotriene B4 receptors 1 and 2 (BLT1 and BLT2). Although BLT1 has potential as a target for treating inflammatory diseases, no selective BLT1 antagonist has been marketed to date.
Alkhodier RA, Alshamrani SA, Almutlaq OS, Alshammari MD.   +3 more
europepmc   +2 more sources

Leukotriene antagonists reduce epileptic seizures-related hospitalization in older adult populations with allergic rhinitis or asthma: A population-based cohort study using the Shizuoka Kokuho database: The Shizuoka study. [PDF]

Epilepsia Open
Objective Managing the risk of epileptic seizures in older adults is increasingly important as the population ages. Leukotriene receptor antagonists (LTRAs) are commonly used to treat asthma or allergic rhinitis.
Imaichi Y, Nakatani E, Fukutomi Y, Kuriyama N, Mori K, Sugawara A.   +5 more
europepmc   +2 more sources

Leukotriene Receptor Antagonists for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-analysis. [PDF]

Acta Derm Venereol
Atopic dermatitis is a chronic skin condition with no cure. Current conventional treatments can have many side effects or are expensive. Emerging evidence suggests leukotriene receptor antagonists could serve as a corticosteroid-sparing option. This meta-
Mahmood SF, Mahmood WN, Abdalla OM, Nazar A, Riaz HZ, Elmorsy S.   +5 more
europepmc   +2 more sources

An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. [PDF]

PLoS ONE, 2013
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory ...
David M Tobin, Francisco J Roca, John P Ray, Dennis C Ko, Lalita Ramakrishnan   +4 more
doaj   +1 more source

Leukotrienes, leukotriene receptor antagonists, and rhinitis [PDF]

Allergy, 2000
A series of clinical studies have shown the ef®cacy of leukotriene (LT) receptor antagonists (LTRAs) in the treatment of bronchial asthma (1±6). LTRAs relieve bronchospasm, prevent exercise-induced asthma, and reduce bronchial hyperresponsiveness.
N, Mygind, R, Dahl, H, Bisgaard
openaire   +2 more sources

Comparative Study to Assess Clinical Efficacy of Leukotriene Receptor Antagonist and Antihistamines in the Treatment of Allergic Rhinitis

Bengal Journal of Otolaryngology and Head Neck Surgery, 2017
Introduction Pharmacologic treatment  options for allergic rhinitis include intranasal corticosteroids, oral and topical antihistamines, decongestants, intranasal cromolyn, intranasal anticholinergics and leukotriene receptor antagonists.
Gurpreet Kaur, Rachna Dhingra, Manjinder Singh   +2 more
doaj   +3 more sources

Leukotriene Receptor Antagonists and Related Compounds

Canadian Respiratory Journal, 1999
Leukotrienes (LTs), lipid mediators of inflammation, have proved to be important biochemicals involved in the symptoms and physiological changes of asthma.
Sally E Wenzel
doaj   +1 more source

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study)

Health Technology Assessment, 2011
Objectives: To evaluate, under real-life practice conditions in UK primary care, asthma control and cost-effectiveness of commencing therapy with leukotriene antagonists compared with inhaled corticosteroids (ICSs) as initial controller therapy and ...
D Price, S Musgrave, E Wilson, E Sims, L Shepstone, A Blyth, J Murdoch, M Mugford, E Juniper, J Ayres, S Wolfe, D Freeman, A Lipp, R Gilbert, I Harvey   +14 more
doaj   +1 more source