Results 21 to 30 of about 13,142 (278)

New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure

, 2023
New leukotriene B4 (LTB4) antagonists have been synthesized that can be considered as potential anti-inflammatory drugs. Structures containing the dioxygenated nucleus of 1,4-benzodioxine constitute a potential group of leukotriene B4 (LTB4) antagonists.
Bouissane, Latifa, Khouili, Mostafa, Guillaumet, Gérald, Coudert, Gérard, Pujol Dilmé, M. Dolors   +4 more
core   +2 more sources

Montelukast and Coronavirus Disease 2019: A Scoping Review

Iranian Journal of Allergy, Asthma and Immunology, 2021
Coronavirus disease 2019 (COVID-19) is an emerging worldwide issue, that has affected a large number of people around the world. So far, many studies have aimed to develop a therapeutic approach against COVID-19.
Niusha Sharifinejad, Samin Sharafian, Sana Salekmoghadam, Marzieh Tavakol, Mostafa Qorbani   +4 more
doaj   +1 more source

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study)

Health Technology Assessment, 2011
Objectives: To evaluate, under real-life practice conditions in UK primary care, asthma control and cost-effectiveness of commencing therapy with leukotriene antagonists compared with inhaled corticosteroids (ICSs) as initial controller therapy and ...
D Price, S Musgrave, E Wilson, E Sims, L Shepstone, A Blyth, J Murdoch, M Mugford, E Juniper, J Ayres, S Wolfe, D Freeman, A Lipp, R Gilbert, I Harvey   +14 more
doaj   +1 more source

Omalizumab: opción terapéutica para la urticaria crónica espontánea de difícil control con vasculitis asociada, reporte de tres casos

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. Aproximadamente el 50 % de los casos de urticaria crónica no mejoran adecuadamente con las dosis convencionales de antihistamínicos, por lo cual se han planteado múltiples opciones terapéuticas, entre las cuales el omalizumab es una ...
Libia Susana Diez, Liliana María Tamayo, Ricardo Cardona   +2 more
doaj   +1 more source

Leukotriene receptor antagonist therapy [PDF]

Postgraduate Medical Journal, 2000
Leukotriene receptor antagonists (LTRA) are a new class of drugs for asthma treatment, available in tablet form. Their unique mechanism of action results in a combination of both bronchodilator and anti-inflammatory effects. While their optimal place in asthma management is still under review, LTRA represent an important advance in asthma ...
openaire   +2 more sources

Effect of a Single Dose Montelukast Sodium on Methacholine Chloride PC20

Canadian Respiratory Journal, 2005
BACKGROUND: It is currently recommended that leukotriene modifiers (receptor antagonists and synthesis inhibitors) be withheld for a minimum of 24 h before direct bronchoprovocation testing, but there is little evidence to support this recommendation.
Beth E Davis, Donald W Cockcroft
doaj   +1 more source

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Nature Communications, 2019
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists ...
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov   +23 more
doaj   +1 more source

Treatment of refractory chronic urticaria

Indian Journal of Dermatology, 2015
Chronic spontaneous urticaria is a distressing disease encountered frequently in clinical practice. The current mainstay of therapy is the use of second-generation, non-sedating antihistamines.
Aayushi Mehta, Kiran Godse, Sharmila Patil, Nitin Nadkarni, Manjyot Gautam   +4 more
doaj   +1 more source

Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Even though the links between upper and lower airway had been of interest to clinicians since long back, it has not attracted the attention of the researchers till recent past.
Apar Jindal, Subramanian Suriyan, Suresh Sagadevan, Meenakshi Narasimhan, Aruna Shanmuganathan, Viswambhar Vallabhaneni, Ragulan Rajalingam   +6 more
doaj   +1 more source

Cross roads between Pulmonology and Psychiatry

Telangana Journal of Psychiatry, 2017
Leukotriene receptor antagonists (Montelukast) has been used for many years in the treatment of asthma in both acute and chronic stages. It is considered safe and is widely used in pediatric age group as well as adults.
M Ajit, K Lokesh Kumar, K Sandeep Krishnamurthy   +2 more
doaj   +1 more source