British Journal of Pharmacology, EarlyView.Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich +7 more
wiley +1 more source
Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. [PDF]
, 2018 Diffuse cutaneous mastocytosis (DCM) is a rare but potentially fatal condition when diagnosis and targeted treatments are delayed. This case illustrates the life-threatening complications in DCM and reviews the currently available treatments.
Akin +32 more
core +1 more source
Pharmacogenetic aspects of basic anti- inflammatory therapy of bronchial asthma in school-aged children under the deletion polymorphism of genes Gstt1 and Gstm1 [PDF]
, 2014 Based on a comprehensive survey of 150 school-age children who suffer from bronchial asthma, there has been found that homozygosity for both alleles of the gene of glutathione transferase (GSTT1+ M1+) was associated with more frequent use both inhaled ...
Bilous, T.M. +3 more
core
Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN) [PDF]
, 2016 Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these ...
A. Cruz +51 more
core +14 more sources
AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes
Clinical &Experimental Allergy, EarlyView.ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron +13 more
wiley +1 more source
Seasonal patterns of oral antihistamine and intranasal corticosteroid purchases from Australian community pharmacies : a retrospective observational study [PDF]
, 2017 Acknowledgments The abstract of this paper was presented at the Respiratory Effectiveness Group 2016 Annual Summit as a poster presentation with interim findings.
Bosnic-Anticevich, Sinthia Z +9 more
core +3 more sources
Mechanism of Cardiac Arrest in Fatal Anaphylaxis
Clinical &Experimental Allergy, EarlyView.This population‐based retrospective cohort study of clinical deterioration in anaphylaxis deaths identifies bronchospasm as the preponderant cause of cardiac arrest, especially in food and drug allergen exposures. The clinical implication is that anaphylaxis guidelines require appropriate emphasis on respiratory involvement and treatment to prevent ...
Ben A. McKenzie +5 more
wiley +1 more source
Chronic urticaria and treatment options
Indian Journal of Dermatology, 2009 Chronic urticaria has a wide spectrum of clinical presentations and causes. Still, despite our best efforts no cause may be found in the majority of cases.
Godse Kiran
doaj
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma [PDF]
, 2014 Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the pharmacogenomic effect of the ...
Ainsworth, Hannah C +11 more
core +2 more sources
Cell Proliferation, EarlyView.This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding +8 more
wiley +1 more source