Results 81 to 90 of about 123,231 (223)

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

Journal of Immunology Research, 2014
Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory
A. J. Theron, H. C. Steel, G. R. Tintinger, C. M. Gravett, R. Anderson, C. Feldman   +5 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Inhibition of Common Cold-Induced Aggravation of Childhood Asthma by Leukotriene Receptor Antagonists

Allergology International, 2012
Background: : Virus infection is an important risk factor for aggravation of childhood asthma. The objective of this study was to examine the effect of drugs on aggravation of asthma induced by a common cold.
Shigemi Yoshihara, Hironobu Fukuda, Toshio Abe, Mitsuhiro Nishida, Yumi Yamada, Noriko Kanno, Osamu Arisaka   +6 more
doaj   +1 more source

Interactions Between the Microbiome and Pharmacotherapy of Allergic Diseases: Current Evidence and Knowledge Gaps

Microbiology Research
The gut microbiota plays an important role in immune homeostasis, allergic disease pathogenesis, and drug metabolism, potentially influencing therapeutic efficacy and safety.
Miljana Poparić, Borko Milanović, David Strilić, Nebojša Pavlović, Vesna Stojanović, Gordana Vijatov-Đurić, Maja Đanić   +6 more
doaj   +1 more source

Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1

, 2020
The cysteinyl leukotrienes (CysLTs), i.e. LTC4, LTD4 and LTE4, are a family of proinflammatory agents synthesized from the arachidonic acid. In target cells, these lipid mediators bind to the cysteinyl leukotriene receptors (CysLTR), a family of seven ...
Limongelli V., Sepe V., Biagioli M., Zampella A., Fiorucci S., Distrutti E., Di Giorgio C., Bordoni M., Fiorucci C., Carino A., Conflitti P., Marchianò S., Baldoni M., Roselli R., Conflitti P, Di Giorgio C, Fiorucci C, Limongelli V, Distrutti E, Bordoni M, Marchianò S, Baldoni M, Biagioli M, Zampella A, Roselli R, Sepe V, Carino A, Fiorucci S   +27 more
core   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial

, 2014
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-
Schmidt, E.B., Schmidt, Lone, Thorlacius-Ussing, Ole; id_orcid, Thorlacius-Ussing, O., Erik Schmidt, Ole Thorlacius-Ussing, Rasmussen, Henrik Højgaard, Lundbye-Christensen, S., Lindhorff-Larsen, K., Lindorff Larsen, Karen, Sorensen, L.S., Calder, P.C., Henrik Rasmussen, Søren Lundbye-Christensen, Rasmussen, H.H., Lundbye-Christensen, Søren; id_orcid, Lone Sorensen, Philip. Calder, Calder, Philip C, Schmidt, Erik Berg, Karen Lindorff-Larsen   +20 more
core   +1 more source

Children Captured in the Swedish National Airway Register Have Increased Familial Atopy, More Severe Disease and Higher Socioeconomic Status

Acta Paediatrica, EarlyView.
ABSTRACT Aim We estimated the coverage of children recorded in the Swedish National Airway Register (SNAR) and identified predictors of registration among those with asthma and moderate to severe asthma. Methods This study comprised 85 656 children aged 5–17 years with asthma, born 2000–2019 and living in Stockholm. The children were identified through
Hanna Karim, Cecilia Lundholm, Bronwyn Brew, Emma Caffrey Osvald, Caroline Stridsman, Resthie R. Putri, Jon Roald Konradsen, Catarina Almqvist   +7 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Structure-based identification of compounds with potential as selective BLT1 antagonists

Scientific Reports
The pro-inflammatory molecule leukotriene B4 binds to the leukotriene B4 receptors 1 and 2 (BLT1 and BLT2). Although BLT1 has potential as a target for treating inflammatory diseases, no selective BLT1 antagonist has been marketed to date.
Reem A. Alkhodier, Saud A. Alshamrani, Omar S. Almutlaq, Maali D. Alshammari   +3 more
doaj   +1 more source