Results 81 to 90 of about 13,142 (278)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Evaluation of the effect of montelukast on cadmium induced toxicity in human embryonic kidney cells (HEK-293) [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2019
Background and Aim: Industrialization of communities has resulted in a rise in cadmium accumulation in the plants, and also organs of human and animals. Kidney is the main target organ for cadmium accumulation and toxicity.
Farnoosh Kaviani, Seyedeh Missagh Jalali, Elham Hoveizi, Javad Jamshidian, Masoomeh Ahmadizadeh   +4 more
doaj   +1 more source

Randomized Controlled Trial of Fish Oil and Montelukast and Their Combination on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction

, 2010
Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB). The purpose of this study was to compare the effects of fish oil and montelukast, alone and in combination, on airway inflammation and ...
Louise A Turner, Turner Louise A., Mickleborough, Timothy D., Joel M Stager, Gregory S. Montgomery, Montgomery, Gregory, Tecklenburg-Lund, Sandra, Turner, Louise A., Montgomery, Gregory S., Alyce D. Fly, Joel M. Stager, Timothy D Mickleborough, Fly, Alyce D., Stager, Joel M., Fly, Alyce, Stager Joel M., Montgomery Gregory S., Mickleborough Timothy D., Timothy D. Mickleborough, Mickleborough, Timothy, Tecklenburg-Lund Sandra, Gregory S Montgomery, Stager, Joel, Louise A. Turner, Fly Alyce D., Turner, Louise, Sandra Tecklenburg-Lund, Alyce D Fly   +27 more
core   +1 more source

Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1

, 2020
The cysteinyl leukotrienes (CysLTs), i.e. LTC4, LTD4 and LTE4, are a family of proinflammatory agents synthesized from the arachidonic acid. In target cells, these lipid mediators bind to the cysteinyl leukotriene receptors (CysLTR), a family of seven ...
Limongelli V., Sepe V., Biagioli M., Zampella A., Fiorucci S., Distrutti E., Di Giorgio C., Bordoni M., Fiorucci C., Carino A., Conflitti P., Marchianò S., Baldoni M., Roselli R.   +13 more
core   +1 more source

A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Among patients with severe eosinophilic asthma, benralizumab was associated with greater improvements in asthma outcomes—such as improved asthma control, quality of life and remission rates—compared to biologic‐naïve patients. ABSTRACT Background Real‐world data on benralizumab in patients with severe eosinophilic asthma–while controlling for ...
Dennis Thomas, Vanessa M. McDonald, Gijo Thomas, Joy Lee, Li Ping Chung, Matthew Peters, Shakti D. Shukla, Yuto Hamada, Erin S. Harvey, Michael Fricker, Hayley See, Rejoy Sabin Thomas, Claude S. Farah, Andrew Gillman, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Peter G. Middleton, Paul Reynolds, Janet Rimmer, Francis Thien, Stephen Vincent, John W. Upham, Peter G. Gibson   +23 more
wiley   +1 more source

Leukotriene modifiers: novel therapeutic opportunities in asthma

, 2002
Cysteinyl leukotrienes (Cys-LT) are powerful proinflammatory autacoids that cause long-lasting bronchoconstriction, plasma leakage, increased mucus production; their biological activity suggests a prominent role in the etiopathology of asthma and several
S. Viappiani, C. Buccellati, F. Fumagalli, G. Folco   +3 more
core   +1 more source

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

Allergy, EarlyView.
Jaime Bernaola, José Antonio Cañas, Álvaro Arranz‐Fragua, José Manuel Rodrigo‐Muñoz, Daniel Rodríguez‐González, Antonio Serrano‐Santiago, Gema Guillén‐Sánchez, Alma Martínez Fernández, Marcela Valverde‐Monge, Diana Betancor, Erwin Javier Pinillos‐Robles, Claudia Rodríguez‐Busto, María Jesús Rodríguez‐Nieto, Joaquín Sastre, Victoria del Pozo   +14 more
wiley   +1 more source

Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma

Clinical &Experimental Allergy, EarlyView.
Forced oscillometry technique defined small airways dysfunction as a treatable trait in asthma. Monoclonal antibodies can improve small airways dysfunction, but their effects vary by mechanism of action. ABSTRACT Small airways dysfunction (SAD) is a recognised treatable trait within severe asthma, associated with worse symptom control and increased ...
Robert Greig, Philipp Suter, Rory Chan, Brian Lipworth   +3 more
wiley   +1 more source

Chronic urticaria and treatment options

Indian Journal of Dermatology, 2009
Chronic urticaria has a wide spectrum of clinical presentations and causes. Still, despite our best efforts no cause may be found in the majority of cases.
Godse Kiran
doaj  

CysLT(1) leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors

, 2005
Montelukast and pranlukast are orally active leukotriene receptor antagonists selective for the CysLT1 receptor. Conversely, the hP2Y1,2,4,6,11,12,13,14 receptors represent a large family of GPCRs responding to either adenine or uracil nucleotides, or to
K. A. Jacobson, Z. G. Gao, V. Capra, M. Fumagalli, FERRARIO, SILVIA, M.R. Accomazzo, M.P. Abbracchio, L. Mamedova, G. Rovati   +8 more
core   +1 more source