Results 61 to 70 of about 13,142 (278)
Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress
Integrative Zoology, EarlyView.Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu +5 more
wiley +1 more source
Allergy, EarlyView.Appropriate treatment escalation improves CSU disease control. However, only about a quarter of patients achieve a complete response, the main goal of CSU treatment. Approximately one‐third of patients clinically eligible for escalation (UCT < 12) do not receive guideline‐recommended treatment escalation and remain symptomatic on their current ...
Pavel Kolkhir +25 more
wiley +1 more source
From the Cochrane Library: Leukotriene Receptor Antagonists for Eczema
JMIR DermatologyLauren Marie Toledo +5 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier +221 more
wiley +1 more source
Leukotrienes and leukotriene modifiers in pediatric allergic diseases
, 2014 Leukotrienes are potent pro-inflammatory lipid mediators derived from arachidonic acid through several enzymatic pathways. They have an essential role in allergic inflammation, where they induce bronchoconstriction, airway edema, and chemotaxis of the ...
El-Ghoneimy, D H, El-Sayed, Z A
core +1 more source
Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells
Allergy, EarlyView.We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller +16 more
wiley +1 more source
PHARMACOLOGICAL APPROACH IN EXERCISE-INDUCED ASTHMA [PDF]
Sport Mont, 2012 Exercise-induced asthma is a transient airflow obstruction, which occurs after the strenuous exercise. It is a complex pathophysiological phenomenon, present in all levels of exercise, from children to professional athletes, so the therapy is specific ...
Biljana Vitošević +2 more
doaj
The problem of preschool wheeze: new developments, new questions
Acta Medica Lituanica, 2010 Preschool wheeze is a common and often difficult to treat symptom. It may rarely be the first presentation of a severe underlying condition. Preschool wheeze is clearly a syndrome, not a single entity, and thus ripe for phenotyping.
Andrew BUSH
doaj +1 more source
Leukotriene antagonists: As firstline asthmatic therapy: A review
, 2005 Asthma is a chronic inflammatory disorder characterized by airflow obstruction. The development of leukotriene receptor antagonists and synthesis inhibitors in briefly described; and acute exercise, allergen, and aspirin challenge, studies with these ...
Roupa, Z., Wozniak, G., Kotrotsiou, E.
core
Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function
Journal of Immunology Research, 2014 Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory
A. J. Theron +5 more
doaj +1 more source