Results 91 to 100 of about 13,142 (278)

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

The Efficacy of Montelukast Monotherapy in Moderate Persistent Asthmatic Children

Iranian Journal of Allergy, Asthma and Immunology, 2009
Although current guidelines place single leukotriene receptor antagonists use as a therapeutic option in mild persistent asthma, there is still uncertainty about its place.
Mahir Igde, Fehim Yasar Anlar
doaj  

Leukotriene Receptor Antagonists in the Treatment of Asthma: Implications for Eosinophilic Inflammation

Canadian Respiratory Journal, 1999
Recent advances in the treatment and management of asthma have suggested that leukotriene (LT) receptor antagonists may be very beneficial as a second generation therapy with steroid-sparing properties and negligible side effects. These agents have shown
Redwan Moqbel
doaj   +1 more source

Consequences of transcellular biosynthesis of leukotriene C4 on organ function

, 1996
Formation of eicosanoids is a special mode of cell communication whereby production of eicosanoids by mixed cell populations differs from that expected from each individual cell.
R. Muller Peddinghaus, F. Berti, G. Rossoni, A. Sala, G. Folco, J. Maclouf   +5 more
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity

Cancer Biology & Therapy
Background Leukotrienes are bioactive lipid mediators produced via the 5-lipoxygenase (5-LO) pathway and are essential for inflammatory signaling in the tumor microenvironment (TME), playing roles in angiogenesis, immune modulation and metastatic ...
Andrew Thake, Maria Caruso, Sebastian Fernandez-Bussy, Keith Sacco   +3 more
doaj   +1 more source

Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor

, 1988
The pharmacological actions of three leukotriene D4 (LTD4) receptor antagonists, FPL-55712, L-648,051, and L-649,923, and a novel inhibitor of leukotriene biosynthesis, L-651,896, have been investigated on isolated human tracheal smooth muscle.
Luc Charette, Danielle Denis, Thomas R. Jones   +2 more
core   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

Leukotriene D₄ and platelet-activating factor – acether antagonists on allergic and arachidonic acid-induced reactions in guinea pig airways

, 1989
Arachidonic acid (AA) and ovalbumin (OA) were used to induce contractions of sensitized guinea pig tracheal spiral (indomethacin-pretreated) and lung parenchymal strip preparations. This model was used to examine the properties of three leukotriene (LT)
John F. Burka, Heather Briand, Franco M. Pasutto, Peter Scott-Savage   +3 more
core   +1 more source

Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5

British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino, Edurne San José‐Enériz, Leire Garate, Estibaliz Miranda, Elena Sáez, Antonio Pineda‐Lucena, Felipe Prósper, Xabier Agirre   +7 more
wiley   +1 more source