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Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation. [PDF]

open access: yesCell Rep
Nagai J   +16 more
europepmc   +1 more source
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Leukotriene-receptor antagonists

Lancet, The, 1999
Leukotriene-receptor antagonists are the first novel class of antiasthma drugs to become available over the past three decades. They have an unique profile in that they are a hybrid of an anti-inflammatory and bronchodilator drug, and they can be taken as a tablet once or twice daily.
Brian Lipworth
exaly   +5 more sources

Leukotriene antagonists

Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire   +2 more sources

Leukotriene and thromboxane antagonists

Clinical Reviews in Allergy, 1994
It has been suggested that arachidonate metabolites, leukotrienes, and thromboxane may play important roles in the pathogenesis of bronchial asthma. Biologic activities of these mediators are much more potent than those of histamine and acetylcholine on a molar basis in inducing bronchoconstriction, increase in microvascular permeability, formation of ...
T, Obata, N, Yamashita, T, Nakagawa
openaire   +2 more sources

Leukotriene Antagonists in Asthma

New England Journal of Medicine, 2011
Aim Cysteinyl leukotrienes are important pro-inflammatory mediators in the pathogenesis of asthma, while leukotriene C 4 synthase is a key enzyme in their biosynthesis. Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme.
Lipworth, Brian, Jackson, Catherine
openaire   +5 more sources

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