Results 191 to 200 of about 21,302 (251)

A Review on Farnesoid X Receptor (FXR) Modulators Focusing on Benzimidazole Scaffold. [PDF]

Molecules
Teno N, Gohda K, Fujimori K.
europepmc   +1 more source

Expert Opinion and Evidence-Based Review on Maintenance Therapy Step-Down in Patients With Severe Asthma Controlled With Biologics. [PDF]

Open Respir Arch
Plaza V, Soto Campos G, Miralles López JC, Padilla Galo A, Martínez Moragón E, Rodríguez F, Mosteiro M, Ausín P, Cebollero P, Quirce S, Almonacid C, Working Group on adjusting maintenance medication in severe asthma with biologics.   +11 more
europepmc   +1 more source

Comparative Efficacy of Montelukast-Levocetirizine Combination Therapy versus Monotherapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Int Arch Allergy Immunol
Kim JS, Stybayeva G, Hwang SH.
europepmc   +1 more source

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Leukotriene antagonists

Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire   +2 more sources

Leukotriene-receptor antagonists

The Lancet, 1999
Leukotriene-receptor antagonists are the first novel class of antiasthma drugs to become available over the past three decades. They have an unique profile in that they are a hybrid of an anti-inflammatory and bronchodilator drug, and they can be taken as a tablet once or twice daily.
openaire   +4 more sources

Leukotriene and thromboxane antagonists

Clinical Reviews in Allergy, 1994
It has been suggested that arachidonate metabolites, leukotrienes, and thromboxane may play important roles in the pathogenesis of bronchial asthma. Biologic activities of these mediators are much more potent than those of histamine and acetylcholine on a molar basis in inducing bronchoconstriction, increase in microvascular permeability, formation of ...
T, Obata, N, Yamashita, T, Nakagawa
openaire   +2 more sources

Leukotriene Antagonists in Asthma

New England Journal of Medicine, 2011
Aim Cysteinyl leukotrienes are important pro-inflammatory mediators in the pathogenesis of asthma, while leukotriene C 4 synthase is a key enzyme in their biosynthesis. Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme.
Lipworth, Brian, Jackson, Catherine
openaire   +5 more sources

[Leukotriene receptor antagonists].

Bioorganicheskaia khimiia, 1993
The review covers the aspects of classification, specificity and structure--biological activity relations in leukotriene receptor antagonists which blockade the action of the acyclic arachidonate metabolites. Prospects of designing new medicines based on these compounds are also discussed.
D M, Kochev, R S, Vorisova, D A, Zabolotskiĭ, G I, Miagkova   +3 more
openaire   +1 more source

Phenylephrine derivatives as leukotriene D4 antagonists

Journal of Medicinal Chemistry, 1987
Two series of phenylephrine derivatives were prepared and tested as inhibitors of leukotriene D4 (LTD4) induced and ovalbumin-induced bronchospasm in the guinea pig. The most potent compound of the urea series, (R)-N,N-diethyl-N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-N- methylurea (3, Wy-47,120), was orally active with ED50's of 56 mg/kg vs.
J H, Musser, D M, Kubrak, R H, Bender, A F, Kreft, S T, Nielsen, A M, Lefer, J, Chang, A J, Lewis, J M, Hand   +8 more
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Leukotriene receptor antagonists in asthma therapy

Journal of Allergy and Clinical Immunology, 2003
In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but ...
Peters, Stephen P., Hamid, Qutayba, Moqbel, Redwan, Sampson, Anthony, Peters-Golden, Marc, Leff, Jon, Pizzichini, Emilio, Edelman, Jon, Liu, Mark, Bisgaard, Hans, Henderson, Bill   +10 more
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