Results 31 to 40 of about 21,302 (251)

気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討 [PDF]

, 2001
The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma.
Ashida, Kozo, Harada, Mine, Hosaki, Yasuhiro, Mifune, Takashi, Mitsunobu, Fumihiro, Okamoto, Makoto, Takada, Shingo, Tanizaki, Yoshiro, Tsugeno, Hirofumi   +8 more
core   +1 more source

Omalizumab: opción terapéutica para la urticaria crónica espontánea de difícil control con vasculitis asociada, reporte de tres casos

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. Aproximadamente el 50 % de los casos de urticaria crónica no mejoran adecuadamente con las dosis convencionales de antihistamínicos, por lo cual se han planteado múltiples opciones terapéuticas, entre las cuales el omalizumab es una ...
Libia Susana Diez, Liliana María Tamayo, Ricardo Cardona   +2 more
doaj   +1 more source

ASSESSMENT OF EFFICACY OF LEUKOTRIENE RECEPTOR ANTAGONISTS IN THERAPY OF BRONCHIAL ASTHMA IN CHILDREN

Педиатрическая фармакология, 2009
The article provides data regarding the clinical efficacy and safety of leukotriene receptor antagonists in treatment of bronchial asthma in children. The only representative of this group that is allowed in Russia for treatment of children over 6 years ...
Yu.G. Levina, L.S. Namazova-Baranova
doaj   +2 more sources

Effect of a Single Dose Montelukast Sodium on Methacholine Chloride PC20

Canadian Respiratory Journal, 2005
BACKGROUND: It is currently recommended that leukotriene modifiers (receptor antagonists and synthesis inhibitors) be withheld for a minimum of 24 h before direct bronchoprovocation testing, but there is little evidence to support this recommendation.
Beth E Davis, Donald W Cockcroft
doaj   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source

Integrating evidence for managing asthma in patients who smoke [PDF]

, 2014
Peer reviewedPublisher ...
Bjermer, Leif, Chisholm, Alison, Popov, Todor A, Price, David   +3 more
core   +1 more source

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Nature Communications, 2019
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists ...
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov   +23 more
doaj   +1 more source

Treatment of refractory chronic urticaria

Indian Journal of Dermatology, 2015
Chronic spontaneous urticaria is a distressing disease encountered frequently in clinical practice. The current mainstay of therapy is the use of second-generation, non-sedating antihistamines.
Aayushi Mehta, Kiran Godse, Sharmila Patil, Nitin Nadkarni, Manjyot Gautam   +4 more
doaj   +1 more source

Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Even though the links between upper and lower airway had been of interest to clinicians since long back, it has not attracted the attention of the researchers till recent past.
Apar Jindal, Subramanian Suriyan, Suresh Sagadevan, Meenakshi Narasimhan, Aruna Shanmuganathan, Viswambhar Vallabhaneni, Ragulan Rajalingam   +6 more
doaj   +1 more source

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Auner, Birgit, Geiger, Emanuel Valentin, Henrich, Dirk, Lehnert, Mark, Marzi, Ingo, Relja, Borna   +5 more
core   +1 more source