Results 41 to 50 of about 21,302 (251)

Cross roads between Pulmonology and Psychiatry

Telangana Journal of Psychiatry, 2017
Leukotriene receptor antagonists (Montelukast) has been used for many years in the treatment of asthma in both acute and chronic stages. It is considered safe and is widely used in pediatric age group as well as adults.
M Ajit, K Lokesh Kumar, K Sandeep Krishnamurthy   +2 more
doaj   +1 more source

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.
Rauf Melekoglu, Osman Ciftci, Aslı Cetin, Nese Basak, Ebru Celik   +4 more
doaj   +1 more source

Churg-Strauss vasculitis in patient who received montelukas [PDF]

Vojnosanitetski Pregled, 2018
Introduction. Montelukast is a selective leukotriene receptor antagonist. One of side effects of this drug class is the Churg-Strauss syndrome (CSS).
Ćupurdija Vojislav, Čekerevac Ivan, Petrović Marina, Kostić Gordana, Suša Romana, Lazić Zorica   +5 more
doaj   +1 more source

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK [PDF]

, 2013
© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Amanda Watt, AR Jadad, British Thoracic Society and Scottish Intercollegiate Guidelines Network, British Thoracic Society Scottish Intercollegiate Guidelines Network, Canadian Academy of Medical Sciences, CE Brightling, D Cooksey, E Nason, E Xystrakis, GK Scadding, House of Lords Science and Technology Committee, J Bott, LA Laitinen, LB Bacharier, Leanne Metcalf, LJ Tata, M Buxton, M Buxton, M Thomas, MA Berry, National Institute for Health Research, P Adam, PA Wark, PE Christie, PE Christie, PJ Jose, PM O’Byrne, PV Dicpinigaitis, R Banzi, R Smith, S Hanney, S Hanney, S Hanney, S Hanney, S Saglani, S Walker, S Wooding, SR Durham, Stephen R Hanney, T Pang, Teresa H Jones, TH Lee, UK Evaluation Forum, WJ Oortwijn, WL Oldfield   +44 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

Frontiers in Pharmacology, 2022
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two highly prevalent human diseases caused by excessive fat deposition in the liver.
Stefano Fiorucci, Pasquale Rapacciuolo, Bianca Fiorillo, Rosalinda Roselli, Silvia Marchianò, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Chiara Cassiano, Paolo Conflitti, Bruno Catalanotti, Vittorio Limongelli, Vittorio Limongelli, Valentina Sepe, Michele Biagioli, Angela Zampella   +15 more
doaj   +1 more source

Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages [PDF]

, 2010
It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma.
Camara, Niels Olsen Saraiva, Hiyane, Meire Ioshie, Landgraf, Maristella de Almeida, Landgraf, Richardt Gama, Pacheco-Silva, Alvaro, Silva, Reinaldo Correia   +5 more
core   +1 more source

Dupilumab Beyond the Airway: Decreased Morbidity in a Real‐World Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real‐world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and ...
Emma J. Anisman, Spencer Short, Emma Tam, Benjamin F. Bitner, Abdulghafoor Alani, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Elina Toskala, Gurston G. Nyquist   +9 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source