Structural basis of leukotriene B4 receptor 1 activation [PDF]
Nature Communications, 2022 In the paper, Dr. Wang et al reported a cryo-EM structure of the human leukotriene B4 receptor 1 (BLT1) in complex with its native ligand leukotriene B4 (LTB4) in an active conformation complexed with Gi protein.
Na Wang +7 more
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The role of leukotriene B4 in cow metritis [PDF]
Journal of Veterinary Research, 2023 Metritis is a common postpartum disease in dairy cows. As a mast cell (MC) mediator, leukotriene B4 (LTB4) is the strongest phagocyte chemokine. It is important in inflammation for the recruitment of immune cells to resist infection.
Wang Guo-Qing +5 more
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Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants [PDF]
BMC Pediatrics, 2023 Background Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth.
Rhea Urs +6 more
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Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma [PDF]
Mediators of Inflammation, 2012 Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Birgit Auner +5 more
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Structural insights on ligand recognition at the human leukotriene B4 receptor 1 [PDF]
Nature Communications, 2021 Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4.
Nairie Michaelian +14 more
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ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion [PDF]
BiomedicinesHere, we demonstrate that human neutrophil interaction with the bacterium Salmonella typhimurium fuels leukotriene B4 synthesis induced by the chemoattractant fMLP.
Ekaterina A. Golenkina +6 more
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Sulfur compounds navigate redox processes, leukotriene synthesis, and ω-hydroxylation of leukotriene B4 in neutrophil interaction with the bacteria Salmonella typhimurium: the way to manipulate neutrophil swarming [PDF]
Frontiers in ImmunologyNeutrophils are the first immune cells recruited by invading pathogens. During interaction with bacteria, neutrophils synthesize leukotriene B4, a potent chemoattractant that, in conjunction with the primary bacterial chemoattractant N-formyl-l-methionyl-
Ekaterina A. Golenkina +6 more
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Neutrophil recruitment depends on platelet-derived leukotriene B4 [PDF]
Blood AdvancesChristian Hackenbroch +8 more
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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021 Background Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy.
Kelvin Yuwanda +5 more
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An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. [PDF]
PLoS ONE, 2013 While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory ...
David M Tobin +4 more
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