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Assay for the leukotriene B4 receptor
1987Publisher Summary This chapter discusses the binding assay in intact cells, membranes, and a detergent-solubilized preparation and a facile neutrophil aggregation assay that can be used to correlate binding data with biological information. The leukotrienes are metabolites of arachidonic acid whose potent biological activities suggest an important ...
R R, Gorman, A H, Lin
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1995
Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Biological activities of leukotriene B4
Agents and Actions, 1981Leukotriene B4 isomer III is released from polymorphonuclear leucocytes, monocytes, eosinophils and macrophages in vitro and has been detected and measured in human synovial fluid in vivo. Its most prominent biological activities are to induce the aggregation of and to stimulate the movement (chemokinesis and chemotaxis) of leucocytes in vitro and it ...
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2015
Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned ...
Tomoaki Koga, Takehiko Yokomizo
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Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned ...
Tomoaki Koga, Takehiko Yokomizo
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Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates
Biochemical and Biophysical Research Communications, 1987A novel isomerase reaction leading to conversion of leukotriene B4 to its 6-trans isomer was detected in rat kidney homogenates. The structure of the metabolite was determined by high performance liquid chromatography, ultraviolet spectrometry and gas-liquid chromatography-mass spectrometry.
O, Breuer, S, Hammarström
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Leukotriene-B4 Receptor and Signal Transduction
2000When cells are stimulated with various agonists, cells release arachidonic acid by the action of phospholipases, and arachidonic acid is further converted to various types of leukotrienes (LTs; Samuelsson et al. 1987; Shimizu and Wolfe 1990; Serhan et al. 1996).
T, Shimizu, T, Yokomizo, T, Izumi
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1987
Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
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Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
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Leukotriene A4 hydrolase and leukotriene B4 metabolism
Journal of Lipid Mediators and Cell Signalling, 1995T, Yokomizo +5 more
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