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The Discovery of the Leukotrienes
American Journal of Respiratory and Critical Care Medicine, 2000In a study of the transformation of polyunsaturated fatty acids in rabbit polymorphonuclear leukocytes in 1976 it was discovered that arachidonic acid is oxygenated at C-5 (1). Subsequently a number of derivatives, including leukotriene B 4 (LTB 4 ), were identified (2-4).
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Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
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Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
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American Journal of Respiratory and Critical Care Medicine, 1998
Abstract Leukotrienes are potent pro-inflammatory mediators that appear to contribute to pathophysiologic features of asthma. For example, cysteinyl leukotrienes contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting eosinophils ...
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Abstract Leukotrienes are potent pro-inflammatory mediators that appear to contribute to pathophysiologic features of asthma. For example, cysteinyl leukotrienes contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting eosinophils ...
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Lipoxygenases and leukotrienes
Journal of Allergy and Clinical Immunology, 1984Abstract Some characteristics of lipoxygenases in general and 5-lipoxygenases in particular are discussed.
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Journal of Receptor Research, 1989
Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions.
J P, Cristol, B, Provençal, P, Sirois
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Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions.
J P, Cristol, B, Provençal, P, Sirois
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The International Journal of Biochemistry & Cell Biology, 1998
Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid. Synthesis is catalysed by 5-lipoxygenase and leukotriene A4 hydrolase and is increased by inflammatory mediators including endotoxin, complement fragments, tumor necrosis factor and interleukins.
S W, Crooks, R A, Stockley
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Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid. Synthesis is catalysed by 5-lipoxygenase and leukotriene A4 hydrolase and is increased by inflammatory mediators including endotoxin, complement fragments, tumor necrosis factor and interleukins.
S W, Crooks, R A, Stockley
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American Journal of Respiratory and Critical Care Medicine, 2000
Allergic rhinitis is characterized by the symptoms of nasal itch, sneezing, rhinorrhea, and nasal stuffiness with, in addition, in more severe and chronic disease the development of mucosal swelling that results in impaired sinus drainage, loss of sense of smell, and alteration in eustachian tube function (1).
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Allergic rhinitis is characterized by the symptoms of nasal itch, sneezing, rhinorrhea, and nasal stuffiness with, in addition, in more severe and chronic disease the development of mucosal swelling that results in impaired sinus drainage, loss of sense of smell, and alteration in eustachian tube function (1).
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Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B
Biochemical and Biophysical Research Communications, 1980Abstract Leukotriene A was assigned the structure 5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid by the enzymatic conversion of a synthetic product of known stereochemistry into the naturally occurring isomer of 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes.
O, Rådmark +6 more
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Leukotriene A4: Enzymatic conversion to leukotriene C4
Biochemical and Biophysical Research Communications, 1980Abstract An unstable epoxide, leukotriene A4 (5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid), was earlier proposed to be an intermediate in the conversion of arachidonic acid into the slow reacting substance (SRS), leukotriene C4.
O, Rådmark, C, Malmsten, B, Samuelsson
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A novel leukotriene formed by transpeptidation of leukotriene E
Biochemical and Biophysical Research Communications, 1982Abstract A new leukotriene 5(S)-hydroxy-6(R)- S -γ-glutamylcysteine-7,9- trans -11,14- cis -eicosatetraenoic acid (leukotriene F4) was isolated after incubating leukotriene E4 with γ-glutamyltranspeptidase and glutathione. Leukotriene F4 induced contractions of the isolated quinea pig ileum and was less potent in this respect than ...
K, Bernström, S, Hammarström
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