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Annual Review of Biochemistry, 1983
The leukotrienes are a family of biologically active molecules, formed by leukocytes, mastocytoma cells, macrophages, and other tissues and cells in response to immunological and nonimmunological stimuli. They exhibit a number of biological effects such as contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and
Richard H. Green, Paul F. Lambeth
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The leukotrienes are a family of biologically active molecules, formed by leukocytes, mastocytoma cells, macrophages, and other tissues and cells in response to immunological and nonimmunological stimuli. They exhibit a number of biological effects such as contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and
Richard H. Green, Paul F. Lambeth
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Allergy and Asthma Proceedings, 1991
Bronchial asthma is characterized by airways' inflammation and airways' hyperresponsiveness. It is unlikely that the pathophysiology of asthma and bronchial hyperresponsiveness can be explained on the basis of a single cell or a single class of mediators.
T H, Lee, J, Arm
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Bronchial asthma is characterized by airways' inflammation and airways' hyperresponsiveness. It is unlikely that the pathophysiology of asthma and bronchial hyperresponsiveness can be explained on the basis of a single cell or a single class of mediators.
T H, Lee, J, Arm
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PEDIATRICS, 2002
Leukotrienes (LTs) are 5-lipoxygenase products formed from arachidonic acid metabolism. There is compelling evidence that LTs play an important role in the pathogenesis of asthma. LTs affect vascular permeability, mucus production, and smooth muscle constriction, and may contribute to airway remodeling.
H William, Kelly, Hans, Bisgaard
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Leukotrienes (LTs) are 5-lipoxygenase products formed from arachidonic acid metabolism. There is compelling evidence that LTs play an important role in the pathogenesis of asthma. LTs affect vascular permeability, mucus production, and smooth muscle constriction, and may contribute to airway remodeling.
H William, Kelly, Hans, Bisgaard
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Leukotrienes and Atherosclerosis
Current Drug Targets, 2010Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the pathogenesis/progression of atherosclerosis and its serious consequences such as acute myocardial infarction (AMI), stroke, aortic aneurysms, and intimal hyperplasia.
G. Riccioni, M. Bäck, V. Capra
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Pharmacology & Therapeutics, 1990
The leukotrienes are synthesized from essential fatty acids via a 5-lipoxygenase enzyme. Most is known about the four-series leukotrienes derived from arachidonic acid. Leukotriene B4 is a potent chemotactic agent for leukocytes and it induces neutrophil-dependent increased microvascular permeability. Leukotrienes C4, D4 and E4 are bronchoconstrictors;
S D, Brain, T J, Williams
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The leukotrienes are synthesized from essential fatty acids via a 5-lipoxygenase enzyme. Most is known about the four-series leukotrienes derived from arachidonic acid. Leukotriene B4 is a potent chemotactic agent for leukocytes and it induces neutrophil-dependent increased microvascular permeability. Leukotrienes C4, D4 and E4 are bronchoconstrictors;
S D, Brain, T J, Williams
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Prostaglandins and leukotrienes
Current Opinion in Immunology, 1989The eicosanoids are a group of substances with wideranging biological activities which are produced in cells from polyunsaturated fatty acids, particularly arachidonic acid (AA). The enzymes initially involved in the production of eicosanoids and their primary products are a cyclooxygenase, which forms prostaglandin (PG) eridoperoxides, and the various
C W, Parker, W F, Stenson
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Molecular and Cellular Biochemistry, 1985
The in vitro metabolism of leukotriene B4 is initiated by omega-hydroxylation. This reaction is followed by oxidation of the omega-hydroxyl group to a carboxyl group. In vivo extensive beta-oxidation occurs and the main excreted products after administration of leukotriene B4 are water and carbon dioxide. Experiments performed in vitro and in vivo have
S, Hammarström +2 more
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The in vitro metabolism of leukotriene B4 is initiated by omega-hydroxylation. This reaction is followed by oxidation of the omega-hydroxyl group to a carboxyl group. In vivo extensive beta-oxidation occurs and the main excreted products after administration of leukotriene B4 are water and carbon dioxide. Experiments performed in vitro and in vivo have
S, Hammarström +2 more
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Clinical Science, 1984
Background: Feldberg & Kellaway [1] were the first to demonstrate the formation and release from envenomed dog and monkey lungs of a substance which caused a delayed and slow contraction of the guinea-pig jejunum; subsequently, Kellaway & Trethewie [2] described release of a slow-reacting substance (SRS) during acute anaphylaxis of the guinea ...
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Background: Feldberg & Kellaway [1] were the first to demonstrate the formation and release from envenomed dog and monkey lungs of a substance which caused a delayed and slow contraction of the guinea-pig jejunum; subsequently, Kellaway & Trethewie [2] described release of a slow-reacting substance (SRS) during acute anaphylaxis of the guinea ...
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Prostaglandins, 1980
A previously introduced nomenclature for leukotrienes is extended on the basis of the nature of the cysteine substituent and the total number of double bonds in new and earlier described compounds.
B, Samuelsson, S, Hammarström
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A previously introduced nomenclature for leukotrienes is extended on the basis of the nature of the cysteine substituent and the total number of double bonds in new and earlier described compounds.
B, Samuelsson, S, Hammarström
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