Results 71 to 80 of about 68,425 (301)

Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics [PDF]

, 2006
Background: Cysteinyl-leukotrienes are lipid derived mediators involved in asthma. They are able to stimulate eosinophil chemotaxis in vitro. Induced sputum from asthmatics has been shown to contain eosinophil chemotactic activity.
Bousquet, Brightling, Dent, Dworski, Green, Hatzelmann, Laitinen, Leckie, Louis, Louis, Louis, Luijk, Pavord, Romagnoli, Spada, Spanevello, Venge, Yoo   +17 more
core   +1 more source

SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells [PDF]

, 2023
Ebru Ermis, Titli Nargis, Abhishek Kulkarni, Sarah May, Sarah A. Tersey, Raghavendra G. Mirmira, Ryan M. Anderson   +6 more
openalex   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

A review of practical strategies for managing bronchial asthma in conventional medical systems

Indian Journal of Allergy Asthma and Immunology
Bronchial asthma is a chronic airway condition affecting about 10%–12% of adults and 15% of children worldwide. Treatment guidelines vary by asthma nature and severity.
Khadija Abdul Hafiz, Kaleem Ahmad, Mohd Aleemuddin Quamri   +2 more
doaj   +1 more source

Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2

Journal of Lipid Research, 2017
Unresolved experimental Lyme arthritis in C3H 5-lipoxygenase (5-LOX)−/− mice is associated with impaired macrophage phagocytosis of Borrelia burgdorferi.
Yan Zhang, Rachel M. Olson, Charles R. Brown   +2 more
doaj   +1 more source

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source

Lysophospholipid acyltransferases and leukotriene biosynthesis: intersection of the Lands cycle and the arachidonate PI cycle[S]

Journal of Lipid Research, 2019
Leukotrienes (LTs) are autacoids derived from the precursor arachidonic acid (AA) via the action of five-lipoxygenase (5-LO). When inflammatory cells are activated, 5-LO translocates to the nuclear membrane to initiate oxygenation of AA released by ...
Robert C. Murphy, Giancarlo Folco
doaj   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Altered signal pathway in granulocytes from patients with hypercholesterolemia

Journal of Lipid Research, 1999
In the present study the signal transduction of the formyl-Met-Leu-Phe receptor was studied in granulocytes obtained from control subjects and patients with elevated low density lipoprotein levels.
György Paragh, Éva Kovács, Ildikó Seres, Tamás Keresztes, Zoltán Balogh, Jenõ Szabó, Farkas Teichmann, Gabriella Fóris   +7 more
doaj   +1 more source

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]

, 2019
BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A, Coelho, N, Correia, MJ, Gonçalves-Dias, C, Macedo, MP, Monteiro, E, Morello, J, Soto, K, et al.   +7 more
core   +1 more source