Results 61 to 70 of about 35,647 (293)

The Potential of Telomeric G-Quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils

Biomolecules, 2020
Human neutrophils are the first line of defense against bacterial and viral infections. They eliminate pathogens through phagocytosis, which activate the 5-lipoxygenase (5-LOX) pathway resulting in synthesis of leukotrienes.
Ekaterina A. Golenkina, Galina M. Viryasova, Nina G. Dolinnaya, Valeria A. Bannikova, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Occupational asthma follow-up — Which markers are elevated in exhaled breath condensate and plasma?

International Journal of Occupational Medicine and Environmental Health, 2014
Objectives: To search for optimal markers in the exhaled breath condensate (EBC), plasma and urine that would reflect the activity/ severity of occupational asthma (OA) after the withdrawal from the exposure to the allergen. Material and Methods: Markers
Daniela Pelclová, Zdenka Fenclová, Štěpánka Vlčková, Pavlína Klusáčková, Jindřiška Lebedová, Kamila Syslová, Jaromír Běláček, Marek Kuzma, Tomáš Navrátil, Sergey Zakharov, Petr Kačer   +10 more
doaj   +1 more source

NSAID-Exacerbated Respiratory Disease (NERD): From Pathogenesis to Improved Care

Frontiers in Pharmacology, 2020
Nonsteroidal antiinflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by moderate-to-severe asthma and a higher prevalence of chronic rhinosinusitis/nasal polyps, but is a highly heterogeneous disorder with various clinical ...
Seong-Dae Woo, Quoc Quang Luu, Quoc Quang Luu, Hae-Sim Park, Hae-Sim Park   +4 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

The features of bile acids exchange in rats under the influence of corvitin [PDF]

The Ukrainian Biochemical Journal, 2017
Corvitin is a soluble form of quercetin (QUE) and its effects are based on the ability to inhibit the activity of 5-lipoxygenase and to block the formation of leukotrienes.
T. V. Vovkun, P. I. Yanchuk, L. Ya. Shtanova, S. P. Veselskiy, N. B. Filimonova, A. S. Shalamay, V. G. Vedmid   +6 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Anti-leukotrienes in asthma and allergic rhinitis.

, 2009
Leukotrienes are lipid mediators synthesized from arachidonic acid liberated from the membranes of activated inflammatory cells [1]. The subfamily of cysteinyl-leukotrienes (cys-LTs) represented by LTC4, LTD4 and LTE4 are the first inflammatory mediators
Sampson, Anthony Peter, Anthony Peter Sampson   +1 more
core   +1 more source

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology

, 2005
We examined the effects of various leukotriene synthesis inhibitors on calcium signalling in HeLa cells, before and after transfection with BLT1. All of the inhibitors studied were found to reduce increases in intracellular calcium concentration induced ...
Haeggstrom, JZ, Bristulf, Jesper, Owman, C, Karlsson, Ulf, Sabirsh, A, Owman, Christer, Karlsson, U, Bristulf, J   +7 more
core   +1 more source