Results 51 to 60 of about 28,774 (254)

Impact of China's National Volume‐Based Procurement Policy on Cost, Volume, and Market Structure: An Interrupted Time‐Series Analysis of Montelukast Sodium

Health Care Science, EarlyView.
Using ARIMA‐based interrupted time‐series analysis, this study reveals that China's NVBP policy significantly reduced daily costs and enhanced affordability, driving generic substitution and the elimination of low‐quality products. Additionally, non‐winning manufacturers adopted strategic pricing behaviors to segment the market.
Yufei Cheng, Fanyu Liu, Yongyi Wu, Siyu Liu, Xiaohan Fan, Bin Jiang, Zhao Yang   +6 more
wiley   +1 more source

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms

Journal of Lipid Research, 2013
Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis.
Pavlos Chaitidis, Susan Adel, Monika Anton, Dagmar Heydeck, Hartmut Kuhn, Thomas Horn   +5 more
doaj   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

LEUKOTRIENES AND ANTILEUKOTRIENE DRUGS IN ALLERGIC RHINITIS

Педиатрическая фармакология, 2009
Allergic rhinitis is an allergic inflammation of the nasal mucosa due to sensitization to some inhalation allergens. There are two phases of a systemic allergic reaction depending on interaction of different cell types a biochemical mediators — the early
M.A. Zharkikh, S.V. Yablonsky, M.A. Mokronosova   +2 more
doaj   +2 more sources

Eicosanoid Control Over Antigen Presenting Cells in Asthma

Frontiers in Immunology, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Nincy Debeuf, Nincy Debeuf, Bart N. Lambrecht, Bart N. Lambrecht, Bart N. Lambrecht   +4 more
doaj   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

A current review on animal models of anti-asthmatic drugs screening

Frontiers in Pharmacology
Asthma is a chronic inflammatory respiratory condition characterised by airway constriction, smooth muscle spasm, and severe morbidity. It affects around 300 million people globally, with children being especially vulnerable. Despite its worldwide effect,
Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma   +5 more
doaj   +1 more source

Unmasking the role of mast cells in dengue

eLife, 2013
Immune cells called mast cells can hinder rather than help the body's response to dengue virus, which suggests that mast cell products could be used as biomarkers to identify severe forms of the disease.
Panisadee Avirutnan, Ponpan Matangkasombut   +1 more
doaj   +1 more source

Knowledge and practice regarding eosinophilic gastrointestinal disorders other than eosinophilic esophagitis among pediatric gastroenterologists of the Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

JPGN Reports, EarlyView.
Abstract Objective Evaluating clinical practices in the management of non‐esophageal eosinophilic gastrointestinal disorders (non‐EoE EGIDs) among pediatric gastroenterologists in Latin America. Methods A cross‐sectional descriptive study was conducted using a survey distributed via the REDCap platform.
Sofia Paz, Michelle Higuera Carrillo, Alonso Rafael Echavez Agudelo, Mário Cesar Vieira, Juan Pablo Riveros López, Natali González Rozó, Gustavo Javier Tagliaferro, Fabiola Sánchez Hernández, Catalina Ortiz Piedrahita, Wilson Daza Carreño, Ailim Margarita Carias Domínguez, José Fernando Vera Chamorro, Sabine Krüger Truppel, Maximiliano Fernández Rivas, César Augusto Moreno Serrano, Pablo Torres Córdova, Carlos Marcelo Timossi, Pablo Vásquez   +17 more
wiley   +1 more source

Cysteinyl Leukotrienes in Eosinophil Biology: Functional Roles and Therapeutic Perspectives in Eosinophilic Disorders

Frontiers in Medicine, 2017
Cysteinyl leukotrienes (cysLTs), LTC4, and its extracellular metabolites, LTD4 and LTE4, have varied and multiple roles in mediating eosinophilic disorders including host defense against parasitic helminthes and allergic inflammation, especially in the ...
Glaucia A. Thompson-Souza, Isabella Gropillo, Josiane S. Neves   +2 more
doaj   +1 more source