Results 111 to 120 of about 2,635,657 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Evolutional Topology Optimization Method Based on Kernel Level Set Function

IEEE Access
Topology optimizations involving evolutionary algorithms are promising approaches to solve practical engineering design problems, since their use of derivation-free algorithms makes them applicable to any design problem.
Takahiro Sato, Kota Watanabe, Hajime Igarashi   +2 more
doaj   +1 more source

Simulation of Continuous Dynamic Recrystallization Using a Level-Set Method. [PDF]

Materials (Basel), 2022
Grand V, Flipon B, Gaillac A, Bernacki M.   +3 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Hybrid Level Set Method for the Topology Optimization of Functionally Graded Structures. [PDF]

Materials (Basel), 2022
Fu J, Shu Z, Gao L, Zhou X.
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Deep level set method for optic disc and cup segmentation on fundus images. [PDF]

Biomed Opt Express, 2021
Zheng Y, Zhang X, Xu X, Tian Z, Du S.
europepmc   +1 more source

A level set method for dislocation dynamics

, 2003
We propose a three-dimensional level set method for dislocation dynamics in which the dislocation lines are represented in three dimensions by the intersection of the zero levels of two level set functions.
Cheng, Li Tien, Srolovitz, David J., Weinan, E., Xiang, Yang   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Level Set Method Based on Interval Analysis

, 2011
Level set methods are used to determine the reachable set for a given time domain. In the aerospace industry level set methods are used to determine for example flight envelopes.
Van Oort, E.R., Chu, Q.P., Elwin de Weerdt, Van Kampen, E., Erik-Jan Van Kampen, De Weerdt, E. (author), De Weerdt, E., Jan Mulder, Van Oort, E.R. (author), Van Kampen, E. (author), Chu, Q.P. (author), Ping Chu, Eddy van Oort   +12 more
core   +1 more source