Results 141 to 150 of about 100,641 (375)

Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats

Drug Design, Development and Therapy, 2012
Xinxin Yang,1,* Yinghui Chen,2,* Xiaoyun Hong,3 Na Wu,1 Lu Song,1 Weien Yuan,3 Zhenguo Liu11Department of Neurology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China; 2Department of Neurology, Jinshan ...
Song L,Yuan W, Wu N, Hong X, Chen Y, Yang X, Liu Z   +5 more
doaj  

Impact of Istradefylline on Levodopa Dose Escalation in Parkinson’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study

Neurology and Therapy
Introduction A higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive treatment to levodopa in PD patients with off episodes, but its impact on levodopa dose titration remains
Taku Hatano, Renpei Sengoku, Hiroshi Nagayama, Naotake Yanagisawa, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Kenichi Kaida, Ryoko Ihara, Kazutomi Kanemaru, Osamu Kano   +28 more
doaj   +1 more source

Managing Dystonia in Partington Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Bilateral focal hand dystonia is an almost pathognomonic sign of Partington syndrome, frequently accompanied by intellectual disability and oromotor dyspraxia. However, a few studies have focused on the treatment of this focal dystonia, making patient management uncertain.
Emilie Pichon, Aurea Alioth, Sabina Catalano Chiuvé, André Zacharia, Marta Ruiz‐Lopez, David P. Breen, Florence Zangas‐Gehri, Florent Draye, Aurore Curie, Duncan Wilson, Victor S.C. Fung, Stephen Duma, Joël Fluss, Julien F. Bally   +13 more
wiley   +1 more source

High Accuracy Classification of Parkinson's Disease through Shape Analysis and Surface Fitting in $^{123}$I-Ioflupane SPECT Imaging

, 2017
Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient ...
Ghosh, Shantanu, Mandal, Pravat K., Prashanth, R., Roy, Sumantra Dutta   +3 more
core   +1 more source

High Cerebrospinal DOPA Decarboxylase Level Predicts Cognitive Decline in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background DOPA decarboxylase (DDC) in cerebrospinal fluid (CSF) is an emerging Parkinson's disease (PD) biomarker, but its association with nonmotor symptoms is unclear. Objectives We aimed to determine if baseline DDC was associated with future cognitive decline in PD.
Andrea Sturchio, Wojciech Paslawski, Shervin Khosousi, Ioanna Markaki, Michael A. Nalls, Andrew B. Singleton, Hirotaka Iwaki, Per Svenningsson   +7 more
wiley   +1 more source

Asymmetric Parietal Cortical Atrophy in a Patient with RAB39B‐Associated Parkinsonism

Movement Disorders Clinical Practice, EarlyView.
Luca Gallo, Emna Ben Mansour, Silvia Nicolosi, Anna Pichiecchio, Simone Gana, Samia Ben Sassi, Silvano Cristina, Micol Avenali, Enza Maria Valente   +8 more
wiley   +1 more source

Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease

Communications Biology
Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can cause undesirable side effects. Additionally, the oral bioavailability of levodopa decreases in Parkinson’s
Gang Cheng, Micael Hardy, Cecilia J. Hillard, Jimmy B. Feix, Balaraman Kalyanaraman   +4 more
doaj   +1 more source

Freezing of Gait in Parkinson’s Disease: A Perceptual Cuase for a Motor Impairment? [PDF]

, 2009
While freezing of gait (FOG) is typically considered a motor impairment, the fact that it occurs more frequently in confined spaces suggests that perception of space might contribute to FOG.
Almeida, Quincy J., Lebold, Chad A.
core   +1 more source

A Holistic Wellness Prescription for Parkinson's Disease: Evidence‐Based Perspectives and Unmet Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background In modern medicine the concept of wellness is often accompanied by various misconceptions arising from several factors, including a lack of clear definitions, the commercialization of wellness, and prevailing biases and stereotypes.
Indu Subramanian, Lucia Ricciardi, Anette Schrag, Silke Appel‐Cresswell, Sushma Kola, Josefa M. Domingos, Barbara A. Pickut, Nabila Dahodwala, Abdoulaye Bocoum, Cristian Falup‐Pecurariu, Gila Bronner, Gregory M. Pontone, Laurie K. Mischley, Nélida S. Garretto, Nicola Modugno, Rachel Dolhun, Tissa Wijeratne, Victoria Tull, Bradley McDaniels, K. Ray Chaudhuri, the International Parkinson, Movement Disorder Society Task Force on Wellness, Indu Subramanian, Lucia Ricciardi, Anette Schrag, Silke Appel‐Cresswell, Sushma Kola, Josefa M. Domingos, Barbara A. Pickut, Nabila Dahodwala, Abdoulaye Bocoum, Cristian Falup‐Pecurariu, Gila Bronner, Gregory M. Pontone, Laurie K. Mischley, Nélida S. Garretto, Nicola Modugno, Rachel Dolhun, Tissa Wijeratne, Victoria Tull, K. Ray Chaudhuri   +40 more
wiley   +1 more source

Simultaneous kinetic-potentiometric determination of levodopa and carbidopa using multivariate calibration methods

, 2020
Mohammad Ali Karimi, Mohammad Hossein Mashhadizadeh, Ardakani M. Mazloum, Nafiseh Sahraei   +3 more
openalex   +1 more source