Results 231 to 240 of about 100,641 (375)
Levodopa exerts neuroprotective effects by suppressing microglial proinflammatory activation in a rat hemi-Parkinson's disease model. [PDF]
Miyaue N +9 more
europepmc +1 more source
Abstract Background Anxiety and autonomic dysfunction are frequent non‐motor symptoms of Parkinson's disease (PD). Their relationship, as well as the neural mechanisms underlying this relationship, remain unexplored. Objectives We aimed to investigate the relationship between cardiovascular functions and anxiety in PD and the structural neural changes ...
Lucia Ricciardi +9 more
wiley +1 more source
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange +8 more
wiley +1 more source
Factors associated with sleep disorders in elderly patients with Parkinson's disease and cognitive impairment and the nomogram model development. [PDF]
Zhang Y, Sun L, Chi H.
europepmc +1 more source
Rare but Relevant? Assessing Variants in Dystonia‐Linked Genes in Parkinson's Disease
Abstract Background Dystonia and Parkinson's disease (PD) exhibit clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective The aim was to assess the frequency of dystonia‐linked pathogenic variants in PD.
Lara M. Lange +37 more
wiley +1 more source
Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations. [PDF]
Ferreira JJ +11 more
europepmc +1 more source
Analyzing the ‘Bradykinesia Complex’ in Parkinson's Disease
Abstract Background Bradykinesia is the hallmark sign of parkinsonism. We recently proposed redefining bradykinesia as a complex of motor abnormalities, each reflecting separate pathophysiological elements. Objective To analyze the ‘bradykinesia complex’ in Parkinson's disease (PD) and healthy elderly individuals.
Giulia Paparella +9 more
wiley +1 more source
Levodopa exposure and nigral neuroinflammation in parkinsonian disorders: A postmortem study of 63 cases. [PDF]
Backman EA +4 more
europepmc +1 more source

