Results 211 to 220 of about 69,629 (300)

Effects of deep brain stimulation on non motor fluctuations in Parkinson's disease (assessed with the NMF severity scale). [PDF]

Clin Park Relat Disord
Matta C, Comet C, Gaillard C, Faggianelli F, Grimaldi S, Witjas T, Ansquer S, Hubsch C, Anheim M, Moreau C, Hainque E, Drapier S, Jarraya B, Laurencin C, Guehl D, Hopes L, Brefel-Courbon C, Tir M, Marques A, Rouaud T, Maltete D, Giordana C, Baumstarck K, Rascol O, Corvol JC, Ory-Magne F, Rolland AS, Devos D, Azulay JP, Eusebio A, PREDISTIM Study Group.   +30 more
europepmc   +1 more source

Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract Deep brain stimulation (DBS) effectively treats motor symptoms in movement disorders but often compromises speech through incompletely defined mechanisms. We conducted a PROSPERO‐registered systematic review and meta‐analysis of publications through August 2024 (CRD42024527738).
Elina Tripoliti, Takashi Tsuboi, Michael T. Barbe, Mario Sousa, Julie Barkmeier‐Kraemer, Hannah Jergas, Gaia Arno, Nicole Buie, Mikayla Day, Petr Krýže, Jayson R. Nelson, Aaron E.L. Warren, Shervin Rahimpour, Jan Rusz, Paul Krack, Kristina Simonyan   +15 more
wiley   +1 more source

The mitogenome mutation repertoire affects progression of Parkinson's Disease. [PDF]

Genet Mol Biol
Matos GB, Santos CSD, Macêdo LCC, Diniz JPDS, Sousa TP, Cavalcante GC, Silva CS, Cruz RLDS, Moura DD, Ribeiro-Dos-Santos A, Santos-Lobato BL, Araújo GS.   +11 more
europepmc   +1 more source

Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction. [PDF]

J Clin Med
Polychronis S, Nasios G, Dardiotis E, Akande R, Pagano G.   +4 more
europepmc   +1 more source

Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa‐Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Movement Disorders, EarlyView.
ABSTRACT Background Dopa‐responsive dystonia is caused by pathogenic variants in the GCH1 gene. Although its clinical features and reduced penetrance are known, in vivo metabolic and structural alterations in symptomatic (sMC) and asymptomatic mutation carriers (aMC) remain poorly understood.
Jannik Prasuhn, Leon van Well, Marta M. Pokotylo, Feline Hamami, Joke‐Lina Aßmann, Katja Lohmann, Maximilian G. Ködderitzsch‐Mertins, Julia Henkel, Jan Uter, Alexander Münchau, Christine Klein, Anne Weissbach, Norbert Brüggemann   +12 more
wiley   +1 more source

Agglomerative clustering-based drugs graded for the risk signals of drug-induced cognitive disorder: a study on the FAERS database. [PDF]

Ther Adv Drug Saf
Lv B, Han J, Yu Y, Li Y.
europepmc   +1 more source

Distinct Brain Drivers and Shared Cerebello–Cortical Input in ADCY5 and SGCE Hyperkinetic Movements

Movement Disorders, EarlyView.
Resting‐state fMRI and effective connectivity revealed distinct cerebellar–basal ganglia–cortical interactions in ADCY5 (MxMD‐ADCY5) and SGCE (MYC/DYT‐SGCE) related movement disorders. The cerebellum modulated cortex directly in MYC/DYT‐SGCE, but indirectly via basal ganglia‐cerebellar projections in MxMD‐ADCY5, which also showed reduced subthalamic ...
Clément Tarrano, Cécile Galléa, Asya Ekmen, Cécile Delorme, Eavan M. McGovern, Quentin Salardaine, Lina Daghsen, Manon Gomes, Vanessa Brochard, Eoin Mulroy, Kailash P. Bhatia, Carlo Fusco, Miryam Carecchio, Norbert Brüggemann, Alexander Münchau, Victoria Gonzalez, Diane Doummar, Christine Tranchant, Mathieu Anheim, Philippe Damier, Florence Riant, Mohamed Doulazmi, Agathe Roubertie, Caroline Dubacq, Oriane Trouillard, Romain Valabregue, Mélanie Didier, Benoit Beranger, Pierre Pouget, Marie Vidailhet, Sabine Meunier, Aurélie Méneret, Yulia Worbe, Emmanuel Roze   +33 more
wiley   +1 more source

Pathogenic Variants in the PRKRA Gene Can Result in a Rapid‐Onset Dystonia‐Parkinsonism‐like Phenotype

Movement Disorders, EarlyView.
Maeve Bradley, Senan Maher, Christian Espinoza‐Vinces, Kathleen Gorman, Tim Lynch, Richard A. Walsh, Alberto J. Espay, Conor Fearon   +7 more
wiley   +1 more source

Mechanistic Insights of Zonisamide in Parkinson's Disease: A Systematic Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Zonisamide is an antiepileptic agent used as adjunctive therapy for Parkinson's Disease in Japan and studied more selectively elsewhere. Preclinical and early translational studies suggest that zonisamide may modulate several pathways relevant to Parkinson's Disease pathobiology, including dopaminergic neurotransmission, oxidative stress ...
Justin Kim, Nathan Chan, Jilai Zhao, Tien K. Khoo   +3 more
wiley   +1 more source

Dual-target magnetic resonance-guided focused ultrasound of the subthalamic and ventral intermediate nuclei for Parkinson's disease: illustrative case. [PDF]

J Neurosurg Case Lessons
Rivera F, Quintanal Cordero N, Barbosa N, Etcheverry JL, Pampin S, Piedimonte F.   +5 more
europepmc   +1 more source