Results 191 to 200 of about 53,685 (285)

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Microbiota-Gut-Brain Axis Interactions with CNS Drugs: A Critical Mechanistic Review of Biopharmaceutical, Pharmacokinetic, and Pharmacodynamic Evidence. [PDF]

Pharmaceutics
Stepensky D.
europepmc   +1 more source

Physical activity and exercise participation—Impact on motor and non‐motor outcomes in early‐stage Parkinson disease: A cross‐sectional study

PM&R, EarlyView.
Abstract Background Aerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long‐term aerobic exercise habits in individuals with early‐stage PD compared with healthy controls. Design Cross‐sectional study.
Cecilie Thrue, Frederik Bonde‐Jensen, Lars G. Hvid, Ulrik Dalgas, Martin Langeskov‐Christensen   +4 more
wiley   +1 more source

Potential Vitamin B6 Depletion During Carbidopa/Levodopa Therapy in Parkinson's Disease: A Scoping Review of Direct Evidence. [PDF]

Cureus
Sielaff P, Lis M, Pawłasek J, Koch RR, Sucharski M, Michałowicz B, Cierpiał P, Puziuk M, Mikołajczak P, Staranowicz A, Dziurzyńska M, Dziurzyński P, Kiełbasiewicz M, Piwar H.   +13 more
europepmc   +1 more source

Natural Glycosides in Neurodegenerative Diseases: Multi‐Target Mechanisms via the Gut–Brain Axis

Phytotherapy Research, EarlyView.
Core pathological features of NDs and the mediating role of the gut_brain axis. The dysregulation of gut microbiota and intestinal barrier leakage trigger systemic inflammation, exacerbating abnormal protein aggregation (such as Aβ and α‐synuclein), oxidative stress, and neuroinflammation in the brain.
Lu Chen, Mengzhen Wei, Qiong Zhang, Lei Jia, Zhihong Zheng, Rui Tan   +5 more
wiley   +1 more source

Reproducible Generalized Thermal Sensation Triggered by Levodopa in a Patient With Parkinson's Disease. [PDF]

J Med Cases
Anuroj K, Paovanit N.
europepmc   +1 more source

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Population pharmacokinetic analyses comparing immediate-release levodopa/carbidopa, controlled-release levodopa/carbidopa, and IPX203. Findings from a phase 1 study in healthy volunteers. [PDF]

J Neural Transm (Vienna)
Wach A, Kopra J, Marjanovic I, Knecht M, Jenner P.   +4 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source