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Unmasking levodopa resistance in Parkinson's disease
Movement Disorders, 2016 Contains fulltext : 168255.pdf (Publisher’s version ) (Open Access)Some motor and nonmotor features associated with Parkinson's disease (PD) do not seem to respond well to levodopa (or other forms of dopaminergic medication) or appear ...
Jorik Nonnekes +2 more
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Clinical Pharmacology & Therapeutics, 1971
Based on the chemical constitution and metabolism of levodopa as well as on the effects of long‐term therapy in patients with parkinsonism, a hypothesis of pharmacologic activity which clearly differentiates it from conventional antiparkinsonian drugs is proposed.
G C, Cotzias +3 more
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Based on the chemical constitution and metabolism of levodopa as well as on the effects of long‐term therapy in patients with parkinsonism, a hypothesis of pharmacologic activity which clearly differentiates it from conventional antiparkinsonian drugs is proposed.
G C, Cotzias +3 more
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Neurology, 1974
We feel it prudent to sound a note of caution about the use of levodopa in patients with known melanomas or with pigmented lesions. Levodopa was administered to three of our patients with Parkinson9s disease and known melanomas or pigmented lesions.
A N, Lieberman, J L, Shupack
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We feel it prudent to sound a note of caution about the use of levodopa in patients with known melanomas or with pigmented lesions. Levodopa was administered to three of our patients with Parkinson9s disease and known melanomas or pigmented lesions.
A N, Lieberman, J L, Shupack
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JAMA: The Journal of the American Medical Association, 1972
To the Editor.— Entitled "Psychiatric Side Effects of Levodopa in Man,"1Frederick Goodwin's article inThe Journaldescribed visual hallucinations among the adverse side effects in Parkinsonian patients treated with levodopa. Prior to this, others2-6described psychosis as an occasional adverse side effect of therapy with levodopa.
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To the Editor.— Entitled "Psychiatric Side Effects of Levodopa in Man,"1Frederick Goodwin's article inThe Journaldescribed visual hallucinations among the adverse side effects in Parkinsonian patients treated with levodopa. Prior to this, others2-6described psychosis as an occasional adverse side effect of therapy with levodopa.
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The American Journal of Nursing, 1974
chronic care facility with no hope of improvement. Parkinsonism is a fairly common, disabling, movement disorder caused by dysfunction of the extrapyramidal system. There are 90 to 110 cases per 100,000 people and an annual incidence of 20 cases per 100,000 people in the United States(1).
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chronic care facility with no hope of improvement. Parkinsonism is a fairly common, disabling, movement disorder caused by dysfunction of the extrapyramidal system. There are 90 to 110 cases per 100,000 people and an annual incidence of 20 cases per 100,000 people in the United States(1).
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Neurology, 1998
Whether a drug such as levodopa, which is prescribed for long periods, may be toxic is a legitimate and even indispensable question. The problem is no different from that posed by other drugs-such as calcium antagonists, antihypertensives, or hormones-normally prescribed for chronic diseases. What, however, is meant in this context by "toxic" (from the
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Whether a drug such as levodopa, which is prescribed for long periods, may be toxic is a legitimate and even indispensable question. The problem is no different from that posed by other drugs-such as calcium antagonists, antihypertensives, or hormones-normally prescribed for chronic diseases. What, however, is meant in this context by "toxic" (from the
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Annals of Internal Medicine, 1980
Excerpt To the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as ...
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Excerpt To the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as ...
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Determination of Purity of Levodopa and Levodopa Products by GLC
Journal of Pharmaceutical Sciences, 1974A simple GLC procedure for the detection and quanti-tation of possible impurities in levodopa raw material and commercial dosage forms is presented. The sample is reacted with N,O-bis(trimethylsilyl)acetamide in acetonitrile at ambient temperature for 30 min, and the silyl derivatives are separated on a methyl silicone column under isothermal ...
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