Results 251 to 260 of about 100,641 (375)

Feasibility of Simon Two‐Stage Futility Trials in People with Early, Symptomatically Treated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch, Lorraine V. Kalia, Justyna Sarna, Camila Aquino, Daryl Wile, Tiago A. Mestre, Michael G. Schlossmacher, Miguel D'Haeseleer, Jop Mostert, Eva M.M. Strijbis, Bernard Uitdehaag, Tarrant McPherson, Gary Cutter   +12 more
wiley   +1 more source

Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson’s disease

, 2000
Valérie Fraix, Pierre Pollak, N. Van Blercom, Junxia Xie, Paul Krack, Adnan Koudsié, Alim Louis Benabid   +6 more
openalex   +2 more sources

Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson's disease experiencing wearing off. [PDF]

Front Neurol
Yu C, Liu W, Gong A, Ye M, Huang H, Zhao Y, Liu C, Guo Y, Chen J, Zhang X, Chen X, Shen L, Li D.   +12 more
europepmc   +1 more source

Long term motor complications of levodopa: clinical features, mechanisms, and management strategies [PDF]

, 2004
Bhomraj Thanvi, T C N Lo
openalex   +1 more source

Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency

Movement Disorders, EarlyView.
Abstract Background Allan‐Herndon‐Dudley syndrome (AHDS)/monocarboxylate transporter 8 (MCT8) deficiency is a rare X‐linked encephalopathy caused by SLC16A2 variants, impairing thyroid hormone (TH) transport into the brain. This leads to early central nervous system (CNS) TH deficiency, affecting brain maturation.
Fabio Bruschi, Ylenia Vaia, Clara E. Antonello, Marco Spada, Francesco Porta, Cristina Marinaccio, Claudia Carducci, Thomas Opladen, Jacopo Sartorelli, Federica Maria Zibordi, Daniele Ghezzi, Francesco Nicita, Davide Tonduti   +12 more
wiley   +1 more source

Sexual Dysfunction in Individuals with Early-Onset Parkinson's Disease in Ethiopia: Gender Differences and Correlation with Anti-Parkinson's Medication, Stigma, and Distress. [PDF]

Healthcare (Basel)
Alenko A, Sudhakar M, Chelkeba L, Keygnaert I.   +3 more
europepmc   +1 more source

MAO‐B and COMT Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease

Journal of clinical pharmacology, 2018
T. Sampaio, E. U. D. Dos Santos, G. D. de Lima, Rute Salgues Gueiros Dos Anjos, R. C. da Silva, A. G. Asano, N. Asano, S. Crovella, P. R. E. de Souza   +8 more
semanticscholar   +1 more source

Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Many patients with Parkinson's disease (PD) have motor impairments despite dopaminergic therapy. Low‐intensity transcranial ultrasound stimulation (TUS) is a non‐invasive neuromodulation method with high spatial precision. The effects of motor cortex (M1) and internal globus pallidus (GPi) TUS on PD motor signs and cortical ...
Yi‐Ying Lin, Nasem Raies, Talyta Grippe, Carolyn A. Gunraj, Can Sarica, Utpal Kumar Saha, Amitabh Bhattacharya, Ghazaleh Darmani, Robert Chen   +8 more
wiley   +1 more source

Microbial Metabolism of Levodopa as an Adjunct Therapeutic Target in Parkinson's Disease. [PDF]

Antioxidants (Basel)
Feix JB, Cheng G, Hardy M, Kalyanaraman B.   +3 more
europepmc   +1 more source

Real-Life Use of Levodopa/Carbidopa Intestinal Gel in Parkinson’s Disease According to Analysis of Pump Data

, 2020
Dag Nyholm, Malak Adnan, Marina Senek
openalex   +2 more sources