Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration
Brain Pathology, EarlyView.Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk +6 more
wiley +1 more source
α‐Synuclein strain homogeneity in multiple system atrophy subtypes
Brain Pathology, EarlyView.Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau +10 more
wiley +1 more source
Cognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies: The Role of Dysautonomia. [PDF]
NeurologyMahajan A +11 more
europepmc +1 more source
Poverty Over the Life Course: Evidence From Birth to Emerging Adulthood
Family Relations, EarlyView.ABSTRACT Objective To assess if childhood poverty predicts poverty in emerging adulthood and identify the mechanisms. Background Early‐life poverty elevates the risk of adult economic disadvantage, but the specific pathways require clearer delineation.
Chien‐Chung Huang, Hui‐Fen Lin
wiley +1 more source
The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases
Immunology &Cell Biology, EarlyView.UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng +3 more
wiley +1 more source
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim To explore how family resilience emerges and unfolds in dementia. Design Qualitative meta‐synthesis using thematic synthesis. Data Sources PubMed, CINAHL, Web of Science, PsycINFO were searched from inception through August 26, 2025. Methods Studies examining family‐level resilience, adaptation or coping in home‐based dementia care using ...
Yoosun Yang, Jun‐Ah Song
wiley +1 more source
Dementia with lewy bodies - diagnosis and treatment
Swiss Medical Weekly, 2003 IG McKeith
doaj +1 more source
Locus coeruleus alterations in dementia with Lewy bodies: A systematic review. [PDF]
Alzheimers Dement (N Y)Bain A +5 more
europepmc +1 more source
A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce +8 more
wiley +1 more source
Retraction Note: Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. [PDF]
Sci RepHassen GW +9 more
europepmc +1 more source