Results 181 to 190 of about 8,460,931 (324)

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Dorsal and ventral stream visuoperceptual processing deficits in Lewy body disease. [PDF]

J Neurol
McCann E, Coleman F, Lee S, Fazlollahi A, O'Sullivan JD, Nestor PJ.   +5 more
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Conscious vision: investigating visual hallucination awareness in Lewy body disease. [PDF]

Brain Commun
Conti D, Accinni T, Teghil A, Ffytche D, Zazzaro G, Panigutti M, Bechi Gabrielli G, Suppa A, Fiorelli M, Caramia F, Bruno G, Guariglia C, D'Antonio F.   +12 more
europepmc   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

High-Resolution Diffusion Tensor Imaging of the Hippocampus and Associations With Neuropsychiatric Symptoms in Lewy Body Diseases. [PDF]

Hippocampus
Budd AS, Solar KG, Gee M, Nelles K, Mankasingh B, Ismail Z, Smith EE, Martyna M, Ba F, Kalra S, Beaulieu C, Camicioli R.   +11 more
europepmc   +1 more source

Molecular Pathology of Lewy Body Diseases

Lewy body diseases are characterized by the presence of Lewy bodies, alphasynuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in ...
Ariza Fernández, A., Domingo Sàbat, Montserrat, Beyer, Katrin   +2 more
core  

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Plasma multi-miRNA models classify Alzheimer's, Parkinson's, and Lewy body dementia. [PDF]

Front Aging Neurosci
Sandau US, Wiedrick JT, McFarland TJ, Yearout D, Zabetian CP, Hu SC, Tsuang DW, Quinn JF, Saugstad JA.   +8 more
europepmc   +1 more source