Results 191 to 200 of about 8,460,931 (324)

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Metabolism Pathway Blood Proteomic Differences in Lewy Body Dementia Compared to Alzheimer's Disease. [PDF]

Int J Mol Sci
Pritha AN, Chouliaras L, Swann P, Prats-Sedano M, McKeever A, Heslegrave A, Ashton NJ, Zetterberg H, Su L, Malpetti M, Rowe JB, O'Brien JT.   +11 more
europepmc   +1 more source

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

Brain Pathology, EarlyView.
This is the first report of neuropathology in biallelic RFC1 expansion‐associated Parkinson’s disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia) features were absent.
Jussi Sipilä, Tuomas Rauramaa, Laura Kytövuori, Kari Majamaa   +3 more
wiley   +1 more source

Reply: Matters Arising ‘Lewy body disease or diseases with Lewy bodies?’

npj Parkinson's Disease, 2022
Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo, Raymond Rosales, Lucie Tučková, Jiří Ehrmann, Dominik Hraboš, Kristýna Kolaříková, Radek Vodička, Radek Vrtěl, Martin Procházka, Martin Nevrlý, Michaela Kaiserová, Sandra Kurčová, Pavel Otruba, Petr Kaňovský   +15 more
doaj   +1 more source

Poverty Over the Life Course: Evidence From Birth to Emerging Adulthood

Family Relations, EarlyView.
ABSTRACT Objective To assess if childhood poverty predicts poverty in emerging adulthood and identify the mechanisms. Background Early‐life poverty elevates the risk of adult economic disadvantage, but the specific pathways require clearer delineation.
Chien‐Chung Huang, Hui‐Fen Lin
wiley   +1 more source

An Ecological and Processual Understanding of Family Resilience in Dementia: A Qualitative Meta‐Synthesis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how family resilience emerges and unfolds in dementia. Design Qualitative meta‐synthesis using thematic synthesis. Data Sources PubMed, CINAHL, Web of Science, PsycINFO were searched from inception through August 26, 2025. Methods Studies examining family‐level resilience, adaptation or coping in home‐based dementia care using ...
Yoosun Yang, Jun‐Ah Song
wiley   +1 more source

Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression. [PDF]

Acta Neuropathol
Luna E, Cousins KAQ, Emrani S, Xie SX, Trotman W, Capp N, Sabatini P, Pouladvand P, Suh E, Van Deerlin VM, Weintraub D, Chen-Plotkin AS, Lee EB, Irwin DJ.   +13 more
europepmc   +1 more source

A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce, Steven Balog, Rachel Gaither, Melissa R. Pfeiffer, Fiona Bhondoekhan, Brian R. Ott, Seth A. Margolis, Alison E. Curry, Andrew R. Zullo   +8 more
wiley   +1 more source

Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases. [PDF]

EBioMedicine
Konuri A, Leal GC, Zebarjadi N, Habich A, Castellanos-Perilla N, Gonzalez MC, Taylor JP, Firbank M, Alcolea D, Bejanin A, Segers K, Benoit F, Isik AT, Samanci B, Cháfer-Pericás C, Wade-Martins R, Hu MTM, Bhome R, Dobreva I, Walker Z, Aarsland D, Westman E, Ferreira D, Halliday G, Lewis SJG, Weil RS, Landin-Romero R, Lambert C, Oxtoby NP, Matar E.   +29 more
europepmc   +1 more source

Effects of the WeCareAdvisor Web App on Behavioral Symptoms and Caregiver Outcomes: A Randomized Trial

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Nonpharmacological strategies are first‐line treatments for behavioral symptoms, the most distressful aspect of dementia care. Few caregivers have knowledge of or access to effective strategies. We tested the effects of WeCareAdvisor, a web app to help caregivers problem‐solve and identify nonpharmacological strategies to manage ...
Laura N. Gitlin, Leslie A. McClure, Melinda J. Webster, Constantine Lyketsos, Helen C. Kales   +4 more
wiley   +1 more source