Results 51 to 60 of about 8,460,931 (324)

Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation [PDF]

, 2020
Objectives: Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality, more intense neuropsychiatric symptoms, more caregivers' burden, and higher costs ...
Clarke, E, Bidkhori, Gholamreza, Rajkumar, Anto P., Ballard, C, Morrin, Hamilton, Morrin, H, Hye, A, Clarke, Emily, Francis, Paul, Shoaie, Saeed; id_orcid, Hye, Abdul, Williams, Gareth; id_orcid, Williams, Gareth, Hye, Abdul; id_orcid, Aarsland, Dag; id_orcid, Rajkumar, AP, Aarsland, Dag, Shoaie, S, Shoaie, Saeed, Rajkumar, Anto P; id_orcid, Bidkhori, G, Francis, P, Aarsland, D,, Ballard, Clive, Francis, Paul; id_orcid, Williams, G   +25 more
core   +1 more source

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

Acta Neuropathologica Communications, 2020
Neurons of the nucleus basalis of Meynert (nbM) are vulnerable to Lewy body formation and neuronal loss, which is thought to underlie cognitive dysfunction in Lewy body dementia (LBD).
Christopher Hatton, Amy Reeve, Nichola Zoe Lax, Alasdair Blain, Yi Shiau Ng, Omar El-Agnaf, Johannes Attems, John-Paul Taylor, Doug Turnbull, Daniel Erskine   +9 more
doaj   +1 more source

Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials

Alzheimer’s Research & Therapy, 2020
Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson’s disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society.
Jennifer G. Goldman, Leah K. Forsberg, Bradley F. Boeve, Melissa J. Armstrong, David J. Irwin, Tanis J. Ferman, Doug Galasko, James E. Galvin, Daniel Kaufer, James Leverenz, Carol F. Lippa, Karen Marder, Victor Abler, Kevin Biglan, Michael Irizarry, Bill Keller, Leanne Munsie, Masaki Nakagawa, Angela Taylor, Todd Graham   +19 more
doaj   +1 more source

Probable dementia with Lewy body [PDF]

Romanian Journal of Neurology, 2017
V.A. female, 67 years, old admitted in our clinic for neurological assessment because of a Parkinson syndrome, in association with neurocognitive disorder established in a psychiatric service.
Irene Davidescu
doaj   +1 more source

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus

Alzheimer’s Research & Therapy, 2022
Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice.
John T. O’Brien, Leonidas Chouliaras, Janet Sultana, John-Paul Taylor, Clive Ballard, on behalf of the RENEWAL Study Group   +5 more
doaj   +1 more source

Plasma Phospho‐Tau Identifies Alzheimer's Co‐Pathology in Patients with Lewy Body Disease

Movement Disorders, 2020
Alzheimer's disease co‐pathology is common in dementia with Lewy bodies and Parkinson's disease with dementia (Lewy body disease) and can reliably be detected with positron emission tomography (PET) or cerebrospinal fluid (CSF) biomarkers.
S. Hall, S. Janelidze, E. Londos, A. Leuzy, E. Stomrud, J. Dage, O. Hansson   +6 more
semanticscholar   +1 more source

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease

PLoS Pathogens, 2021
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites ...
Soo Jin Park, Uram Jin, Sang Myun Park
doaj   +2 more sources

Dementia With Lewy Bodies

Archives of Neurology, 2003
The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's ...
McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT   +10 more
  +9 more sources

Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

Nature Neuroscience
Recent studies suggest the existence of brain-first and body-first subtypes within the Lewy body disorder (LBD) spectrum, including Parkinson’s disease.
Katrine B. Andersen, Anushree Krishnamurthy, M. K. Just, N. Van Den Berge, Casper Skjærbæk, J. Horsager, K. Knudsen, Jacob W. Vogel, Jon B. Toledo, J. Attems, T. Polvikoski, Yuko Saito, Shigeo Murayama, P. Borghammer   +13 more
semanticscholar   +1 more source

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Molecular Neurodegeneration, 2009
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major component of the Lewy body, the mechanisms by which neurons
Perry George, Castellani Rudy J, Takeda Atsushi, Choi Raymond, Kondo Eisaku, Siedlak Sandra L, Chen Shu G, Wang Xinglong, Liu Haihua, Su Bo, Smith Mark A, Zhu Xiongwei, Lee Hyoung-gon   +12 more
doaj   +1 more source