Results 41 to 50 of about 8,460,931 (324)

Lewy bodies [PDF]

Proceedings of the National Academy of Sciences, 2006
Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to α-synuclein (α-SYN), which appears to be the major ...
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Dementia with Lewy Bodies [PDF]

Seminars in Neurology, 2014
Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex.
Mary Catherine, Mayo, Yvette, Bordelon
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The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study [PDF]

, 2005
The objective of the study was to identify clinical features that distinguish patients with dementia with Lewy bodies (DLB), who were classified as Alzheimer's disease ( AD) patients, from patients with AD.
Müller, U., Neumann, M., Kretzschmar, H., Perneczky, R., Kurz, A., Förstl, Hans, Mösch, D., Busch, R., Perneczky, R.;Mösch, D.;Neumann, M.;Kretzschmar, H.;Müller, U.;Busch, R.;Förstl, H.;Kurz, A., Perneczky, R;Mosch, D;Neumann, M;Kretzschmar, H;Müller, U;Busch, R;Förstl, H;Kurz, A   +9 more
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The Lewy body [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2001
James Parkinson noted: “A diseased state of the medulla spinalis, in that part which is contained in the canal, formed by the superior cervical vertebrae, and extending, as the disease proceeds, to the medulla oblongata . . .is the proximate cause.”1 In the late 19th century, because knowledge of the pathophysiology of the basal ganglia was imprecise,
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Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]

, 2005
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis.
Cepek, L., Neumann, M., Ciesielczyk, Barbara, Cepek, Lukas, Neumann, Manuela, Trenkwalder, C., Kretzschmar, Hans A., Otto, M., Mollenhauer, B., Schulz-Schaeffer, W. J., Poser, Sigrid, Otto, Markus, Ciesielczyk, B., Steinacker, Petra, Steinacker, P., Wiltfang, J., Schulz-Schaeffer, Walter J., Poser, S., Bibl, Mirko, Mollenhauer, Brit, Trenkwalder, Claudia, Bibl, M., Wiltfang, Jens, Kretzschmar, H. A.   +23 more
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Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

Acta Neuropathologica, 2020
The clinical diagnosis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an early disease stage, due to the heterogeneous and often non-specific ...
Marcello Rossi, Niccolò Candelise, Simone Baiardi, S. Capellari, G. Giannini, C. Orrú, E. Antelmi, A. Mammana, A. Hughson, G. Calandra-Buonaura, A. Ladogana, G. Plazzi, P. Cortelli, B. Caughey, Piero Parchi   +14 more
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Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG   +30 more
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Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

bioRxiv, 2020
Misfolded α-synuclein is a major component of Lewy bodies, which are a hallmark of Parkinson’s disease. A large body of evidence shows that α-synuclein can self-assemble into amyloid fibrils, but the relationship between amyloid formation and Lewy body ...
M. Hardenberg, T. Sinnige, Sam Casford, Samuel T Dada, C. Poudel, Liz Robinson, M. Fuxreiter, Clemens Kaminksi, G. K. Kaminski Schierle, E. Nollen, C. Dobson, M. Vendruscolo   +11 more
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Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

Annals of Neurology, 2020
Objective: To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings with Lewy body synucleinopathies. Methods: In a
W. Singer, A. Schmeichel, M. Shahnawaz, J. Schmelzer, B. Boeve, D. Sletten, T. Gehrking, Jade A. Gehrking, A. D. Olson, R. Savica, M. Suarez, C. Soto, P. Low   +12 more
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Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies [PDF]

, 2007
Background: The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases.
Steinacker, Petra, Brechlin, Peter, Bahn, Erik, Bibl, Mirko, Locascio, Joseph J., Kretzschmar, Hans A., Mollenhauer, Brit, Trenkwalder, Claudia, Schlossmacher, Michael G., Poser, Sigrid, Otto, Markus, Wiltfang, Jens   +11 more
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