Results 21 to 30 of about 8,460,931 (324)

Neuropathology of incidental Lewy body & prodromal Parkinson’s disease

Molecular Neurodegeneration, 2023
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there is currently no disease-modifying treatment to halt neuronal loss in PD.
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schließer, Felix L. Struebing, M. Brendel, Johannes Levin, C. Trenkwalder, G. Höglinger, J. Herms   +8 more
semanticscholar   +1 more source

Lewy Body Dementia Association’s Industry Advisory Council: proceedings of the second annual meeting

Alzheimer’s Research & Therapy, 2021
In 2019, the Lewy Body Dementia Association formed an Industry Advisory Council to bring together a collaborative group of stakeholders with the goal of accelerating clinical research into Lewy body dementia treatments.
Jennifer G. Goldman, Bradley F. Boeve, Melissa J. Armstrong, Doug R. Galasko, James E. Galvin, David J. Irwin, James B. Leverenz, Karen Marder, Victor Abler, Kevin Biglan, Michael C. Irizarry, Bill Keller, Robert Lai, Leanne Munsie, Michael Belleville, Ondrea Chaney, Ian Richard, Angela Taylor, Todd Graham   +18 more
doaj   +1 more source

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Nature Genetics, 2021
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia ...
R. Chia, M. Sabir, S. Bandres-Ciga, S. Saez-Atienzar, R. Reynolds, E. Gustavsson, Ronald L. Walton, Sarah Ahmed, C. Viollet, Jinhui Ding, Mary B Makarious, M. Diez-Fairen, Makayla K Portley, Zalak V. Shah, Yevgeniya A. Abramzon, D. Hernandez, C. Blauwendraat, David J. Stone, J. Eicher, L. Parkkinen, O. Ansorge, L. Clark, L. Honig, K. Marder, A. Lemstra, P. S. St George-Hyslop, E. Londos, K. Morgan, T. Lashley, T. Warner, Z. Jaunmuktane, D. Galasko, I. Santana, P. Tienari, L. Myllykangas, M. Oinas, N. Cairns, J. Morris, G. Halliday, V. V. Van Deerlin, J. Trojanowski, M. Grassano, A. Calvo, G. Mora, A. Canosa, G. Floris, Ryan C. Bohannan, F. Brett, Z. Gan-Or, Joshua T. Geiger, A. Moore, P. May, R. Krüger, David S. Goldstein, G. Lopez, N. Tayebi, E. Sidransky, L. Norcliffe-Kaufmann, J. Palma, H. Kaufmann, V. Shakkottai, Matthew Perkins, K. Newell, T. Gasser, C. Schulte, F. Landi, E. Salvi, D. Cusi, E. Masliah, R. Kim, Chad A. Caraway, E. Monuki, M. Brunetti, T. Dawson, L. Rosenthal, M. Albert, O. Pletnikova, J. Troncoso, Margaret E. Flanagan, Qinwen Mao, E. Bigio, E. Rodríguez-Rodríguez, J. Infante, C. Lage, I. González‐Aramburu, P. Sánchez-Juan, B. Ghetti, J. Keith, S. Black, M. Masellis, E. Rogaeva, C. Duyckaerts, A. Brice, S. Lesage, G. Xiromerisiou, M. Barrett, B. Tilley, S. Gentleman, G. Logroscino, G. Serrano, T. Beach, I. McKeith, Alan J. Thomas, J. Attems, C. Morris, L. Palmer, S. Love, C. Troakes, S. Al-Sarraj, A. Hodges, D. Aarsland, G. Klein, S. M. Kaiser, R. Woltjer, P. Pastor, L. Bekris, J. Leverenz, Lilah M. Besser, Amanda Kuzma, A. Renton, A. Goate, D. Bennett, C. Scherzer, H. Morris, R. Ferrari, D. Albani, S. Pickering-Brown, K. Faber, W. Kukull, E. Morenas-Rodriguez, A. Lleó, J. Fortea, D. Alcolea, J. Clarimón, M. Nalls, L. Ferrucci, S. Resnick, Toshiko Tanaka, T. Foroud, N. Graff-Radford, Z. Wszolek, T. Ferman, B. Boeve, J. Hardy, E. Topol, A. Torkamani, A. Singleton, M. Ryten, D. Dickson, A. Chiò, O. Ross, J. R. Gibbs, C. Dalgard, B. Traynor, Sonja W. Scholz   +154 more
semanticscholar   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Weintraub D, York MK, Dobkin R, Nair AR, Kurth R, Lafontant DE, Caspell-Garcia C, Alcalay RN, Brown EG, Chahine LM, Coffey C, Foroud T, Galasko D, Kieburtz K, Marek K, Merchant K, Mollenhauer B, Poston KL, Siderowf A, Simonet C, Simuni T, Tanner CM, Tropea TF, Videnovic A, Parkinson's Progression Markers Initiative.   +24 more
europepmc   +2 more sources

Dementia with Lewy Bodies [PDF]

Neurologic Clinics, 2007
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen ...
Tanis J, Ferman, Bradley F, Boeve
openaire   +5 more sources

Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Acta Neuropathologica Communications, 2022
Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies.
S. Hall, C. Orrú, G. Serrano, D. Galasko, A. Hughson, B. Groveman, C. Adler, Thomas G. Beach, B. Caughey, O. Hansson   +9 more
semanticscholar   +1 more source

Working in a care home during the COVID-19 pandemic: How has the pandemic changed working practices? A qualitative study

BMC Geriatrics, 2022
Background The pandemic has significantly affected care homes’ residents and families through the national visiting restrictions. However, less is known on the impact these changes have had on the care home workforce.
Kerry Hanna, Clarissa Giebel, Jacqueline Cannon, Justine Shenton, Stephen Mason, Hilary Tetlow, Paul Marlow, Manoj Rajagopal, Mark Gabbay   +8 more
doaj   +1 more source

Recent advances in Lewy body dementia: A comprehensive review.

Disease-a-month : DM, 2022
Lewy Body Dementia is the second most frequent neurodegenerative illness proven to cause dementia, after Alzheimer's disease (AD). It is believed to be vastly underdiagnosed, as there is a significant disparity between the number of cases diagnosed ...
Sakshi Prasad, M. Katta, Shuchi Abhishek, Rishala Sridhar, Sai Sudha Valisekka, M. Hameed, J. Kaur, Namrata Walia   +7 more
semanticscholar   +1 more source

I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review [PDF]

Journal of Movement Disorders, 2015
Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart.
Eun Joo Chung, Sang Jin Kim
doaj   +1 more source

CD4+ T cells contribute to neurodegeneration in Lewy body dementia

Science, 2021
Description Autoimmunity in Lewy body dementia Lewy body dementia (LBD) is a brain disease that leads to progressive decline in thinking, movement, and independent function.
D. Gate, Emma Tapp, Olivia Leventhal, Marian Shahid, Tim J Nonninger, Andrew C. Yang, Katharina Strempfl, M. S. Unger, T. Fehlmann, H. Oh, D. Channappa, V. Henderson, A. Keller, L. Aigner, D. Galasko, Mark M. Davis, K. Poston, T. Wyss-Coray   +17 more
semanticscholar   +1 more source