Results 11 to 20 of about 8,460,931 (324)
The Lancet, 2015 The broad importance of dementia is undisputed, with Alzheimer's disease justifiably getting the most attention. However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years.
Walker, Zuzana +3 more
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Behavioural Neurology, 1990 In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present,
W. R. G. Gibb
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Annals of Medicine, 1999 Although Lewy body dementia (LBD) has received a considerable amount of interest in the last decade, there still exists a certain level of confusion concerning the clinical and neuropathological features associated with this disorder. According to many researchers, LBD represents a distinct dementing illness with specific clinical features.
Brown, Daniel F, MD, MBA
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Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases [PDF]
Movement Disorders, 2019 PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes characterized by the neuropathological accumulation of alpha‐synuclein in the CNS that represent a clinicopathological spectrum known as Lewy body disorders.
D. Coughlin, H. Hurtig, D. Irwin
semanticscholar +2 more sources
Dementia with Lewy bodies [PDF]
Psychiatry, 1999 Objective: The aim of this paper is to summarise recent clinical and research findings with regard to dementia with Lewy bodies (DLB). Method: A literature review (Medline) was carried out, as well as a review of reports of recent DLB symposia of international meetings and of other relevant papers and data known to the authors.
I, McKeith, J, O'Brien
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A clinicopathological investigation of brainstem nuclei in Lewy body dementia [PDF]
, 2023 Introduction: Lewy Body Dementias (LBD) - Dementia with Lewy Bodies (DLB) and Parkinson’s Disease Dementia (PDD) - are clinical diagnoses based on the one-year rule and varied symptom onset. Previously, degeneration of the locus coeruleus (LC) and dorsal
Patel, Shivani
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Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology
Metabolites, 2021 Ubiquitin Specific Protease-13 (USP13) promotes protein de-ubiquitination and is poorly understood in neurodegeneration. USP13 is upregulated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), and USP13 knockdown via shRNA reduces neurotoxic ...
Xiaoguang Liu +5 more
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Cognitive effects of Lewy body pathology in clinically unimpaired individuals
Nature Medicine, 2023 α-Synuclein aggregates constitute the pathology of Lewy body (LB) disease. Little is known about the effects of LB pathology in preclinical (presymptomatic) individuals, either as isolated pathology or coexisting with Alzheimer’s disease (AD) pathology ...
S. Palmqvist +14 more
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Clinical effects of Lewy body pathology in cognitively impaired individuals
Nature Medicine, 2023 There is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients with cognitive impairment, especially when coexisting with Alzheimer’s disease (AD) pathology (amyloid-β and tau).
C. Quadalti +11 more
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Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Bosutinib, a dual Abelson/Src inhibitor, was investigated in individuals with dementia with Lewy bodies (DLB). Methods A single site, randomized, double‐blind, placebo‐controlled study of the effects of oral bosutinib, 100 mg once daily for ...
Fernando L. Pagan +8 more
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