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Journal of the Anus, Rectum and Colon, 2019 We systematically reviewed literature regarding "Lewy body constipation", i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms.
Ryuji Sakakibara +2 more
doaj +7 more sources
Neuropathological evidence of body-first vs. brain-first Lewy body disease
Neurobiology of Disease, 2021 Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB).
Per Borghammer +7 more
doaj +4 more sources
Lewy body disease or diseases with Lewy bodies?
npj Parkinson's Disease, 2022 The current nosological concept of α-synucleinopathies characterized by the presence of Lewy bodies (LBs) includes Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB), for which the term “Lewy body disease ...
Kateřina Menšíková +15 more
doaj +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Although converging evidence point to α-synuclein aggregation and Lewy body (LB) formation as central events in Parkinson’s disease, the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain elusive.
Hilal Lashuel +2 more
exaly +2 more sources
Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases
Acta NeuropathologicaLewy body diseases are common neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies, which lead to both motor and non-motor symptoms.
Laura Parkkinen +2 more
exaly +2 more sources
Network hierarchy in Alzheimer’s and Lewy body spectrum disorders: functional gradients, cognitive phenotypes, and translational gaps [PDF]
Frontiers in Aging NeuroscienceDementia syndromes alter cortical hierarchy in addition to individual brain regions. Functional connectivity gradients offer a continuous, low-dimensional framework for examining these hierarchy-level changes.
Yujian Liu, Tianjiao Lv, Yuan Li
doaj +2 more sources
Neurologic Clinics, 2017 Dementia syndromes associated with Lewy bodies are subdivided into dementia with Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and Parkinson disease with dementia (PDD), cognitive impairment appearing in people diagnosed with ...
D. Galasko
semanticscholar +3 more sources
Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia [PDF]
Continuum, 2016 This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.DLB and PDD are common, clinically similar syndromes that share characteristic neuropathologic changes, including ...
S. Gomperts
semanticscholar +3 more sources
Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia [PDF]
Nature CommunicationsDementia is a defining feature of Lewy body disease: its timing and onset distinguish different clinical diagnoses, and its effect on quality of life is profound.
Angeliki Zarkali +7 more
doaj +2 more sources
Matters Arising ‘Lewy body disease or diseases with Lewy bodies?’
npj Parkinson's Disease, 2022 Kurt A. Jellinger
doaj +3 more sources