Results 61 to 70 of about 8,460,931 (324)

Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Acta Neuropathologica, 2020
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS).
Zen-ichi Tanei, Yuko Saito, S. Ito, T. Matsubara, A. Motoda, M. Yamazaki, Yasuhiro Sakashita, Ito Kawakami, M. Ikemura, Shinya Tanaka, R. Sengoku, T. Arai, S. Murayama   +12 more
semanticscholar   +1 more source

New evidence on the management of Lewy body dementia

Lancet Neurology, 2019
Dementia with Lewy bodies and Parkinson’s disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with a wide range of cognitive, neuropsychiatric, sleep, motor, and ...
John-Paul Taylor, I. McKeith, D. Burn, B. Boeve, D. Weintraub, C. Bamford, L. Allan, Alan J. Thomas, J. O'Brien   +8 more
semanticscholar   +1 more source

Clinical diagnosis of Lewy body dementia

BJPsych Open, 2020
Background Lewy body dementia, consisting of both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is considerably under-recognised clinically compared with its frequency in autopsy series. Aims This study investigated the clinical
A. Surendranathan, J. Kane, A. Bentley, S. Barker, John-Paul Taylor, Alan J. Thomas, L. Allan, R. McNally, Peter W. James, I. McKeith, D. Burn, J. O'Brien   +11 more
semanticscholar   +1 more source

Lewy body disease and dementia with Lewy bodies

Proceedings of the Japan Academy, Series B, 2014
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type.
openaire   +3 more sources

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

Neuron, 2011
Summary Inclusions comprised of α-synuclein (α-syn), i.e. Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson’s Disease (PD) and dementia with Lewy Bodies (DLB).
L. Volpicelli-Daley, Kelvin C. Luk, Tapan P. Patel, Selcuk A. Tanik, Dawn M. Riddle, Anna Stieber, David F. Meany, J. Trojanowski, V. Lee   +8 more
semanticscholar   +1 more source

Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases

Neuropathology (Kyoto. 1993), 2020
Lewy body disease (LBD) is characterized by the presence of Lewy bodies (LBs) and Lewy neurites and comprises a diagnostic spectrum that includes Parkinson's disease (PD), PD with dementia, and dementia with LBs.
Tomoya Kon, M. Tomiyama, K. Wakabayashi
semanticscholar   +1 more source

Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study

Biology of Sex Differences, 2022
Highlights There are significant sex differences in Chinese population with cognitive impairment in Lewy body disease. Women were more common in dementia with Lewy bodies and mild cognitive impairment with Lewy bodies cases, had more frequent and severe ...
Jinghuan Gan, Zhichao Chen, Zhihong Shi, Xudong Li, Shuai Liu, Yiming Liu, Hongcan Zhu, Lu Shen, Guili Zhang, Yong You, Qihao Guo, Nan Zhang, Yang Lv, Baozhi Gang, Junliang Yuan, Yong Ji   +15 more
doaj   +1 more source

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Scientific Reports, 2019
Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood.
Allison J. Schaser, Valerie R. Osterberg, Sydney E. Dent, Teresa L. Stackhouse, Colin M. Wakeham, S. Boutros, Leah J Weston, N. Owen, T. Weissman, Esteban Luna, J. Raber, Kelvin C. Luk, A. McCullough, R. Woltjer, Vivek K. Unni   +14 more
semanticscholar   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand [PDF]

, 2002
Background: Dementia with Lewy bodies (DLB) is one of the main differential diagnoses of Alzheimer's disease (AD). Key pathological features of patients with DLB are not only the presence of cerebral cortical neuronal loss, with Lewy bodies in surviving ...
Livingston, G, Costa, DC, Shaw, K, Ince, P, Gacinovic, S, Walker, RWH, Stevens, T, Katona, CLE, McKeith, IG, Walker, Z   +9 more
core